DOES BLOOD-TRANSFUSION OR HEMORRHAGIC-SHOCK INDUCE IMMUNOSUPPRESSION
DOES BLOOD-TRANSFUSION OR HEMORRHAGIC-SHOCK INDUCE IMMUNOSUPPRESSION
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DOI：
10.1097/00005373-199205000-00013
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发表时间：
1992-05-01
影响因子：
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通讯作者：
MALANGONI, MA
中科院分区：
文献类型：
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作者：
CUE, JI;PEYTON, JC;MALANGONI, MA
输血通过诱导免疫抑制而使患者易受感染。本研究评价了同基因（ST）和同种异体（AT）输血伴和不伴出血性休克（HS）的影响，以确定输血或伴随的出血是否影响免疫反应的某些成分。刘易斯大鼠接受10%、20%或30%血容量的ST或AT。在其他动物中诱导出血性休克，这些动物用放血或替代10%、20%或30% ST或AT复苏。皮内葡萄球菌脓肿的大小，腹腔白细胞的激发，和腹腔巨噬细胞la受体的表达被选择来衡量免疫系统的反应。出血性休克使脓肿体积显著增大（p < 0.05），但ST或AT单独或与HS联合应用均无影响。休克和输血本身均增加巨噬细胞la受体表达（p < 0.05），但未观察到相加或协同作用。腹膜白细胞激发不受HS、ST或AT的影响。这些结果表明，HS而不是输血是感染风险的主要决定因素。
Blood transfusions have been implicated in predisposing patients to infection by inducing immunosuppression. This study evaluated the effects of syngeneic (ST) and allogeneic (AT) blood transfusion with and without hemorrhagic shock (HS) to determine whether transfusion or the accompanying hemorrhage affected certain components of the immune response. Lewis rats received ST or AT at 10%, 20%, or 30% of blood volume. Hemorrhagic shock was induced in other animals, which were resuscitated with either shed blood or substituted 10%, 20%, or 30% ST or AT. Intradermal staphylococcal abscess size, peritoneal leukocyte elicitation, and peritoneal macrophage la receptor expression were selected to measure the immune system response. Hemorrhagic shock increased abscess size significantly (p < 0.05), but ST or AT alone or in combination with HS had no effect. Both shock and transfusion per se increased macrophage la receptor expression (p < 0.05), but no additive or synergistic effect was observed. Peritoneal leukocyte elicitation was not affected by HS, ST, or AT. These results suggest that HS and not blood transfusion is a major determinant of the risk of infection.