Fully Integrated, Stretchable, Wireless Skin-Conformal Bioelectronics for Continuous Stress Monitoring in Daily Life
Fully Integrated, Stretchable, Wireless Skin-Conformal Bioelectronics for Continuous Stress Monitoring in Daily Life
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DOI：
10.1002/advs.202000810
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发表时间：
2020-08-01
期刊：
影响因子：
15.1
通讯作者：
Yeo, Woon-Hong
中科院分区：
文献类型：
--
作者：
Kim, Hojoong;Kim, Yun-Soung;Yeo, Woon-Hong
压力是增加严重健康问题风险的主要原因之一。最近的可穿戴设备已经被用来通过皮肤上的电皮肤活动来监测压力水平。尽管许多生物传感器提供了足够的传感性能，但它们仍然依赖于不舒服的、部分灵活的系统和刚性电子设备。这些设备要么安装在手指上，要么安装在手掌上，这阻碍了连续的信号监测。这里介绍了一种完全集成的、可伸展的无线皮肤适形生物电子设备(简称SKINTRONICS)，它集成了柔软的、多层的纳米膜传感器和电子设备，用于日常生活中连续和便携的应力监测。SKINTRONICS一体机超薄、高度柔软、重量轻，总体上为皮肤提供符合人体工程学的保形层压。可伸缩纳米膜电极和数字温度传感器可实现对皮肤电流反应(GSR)和温度的高灵敏度监控。一套全面的信号处理、计算建模和实验研究提供了器件设计、制造和最佳放置位置的关键方面。同时与两种商用压力监测器进行比较，可以看出SKINTRONICS在长期耐磨性、最小噪音和皮肤兼容性方面的增强性能。日常生活中连续应力监测的活体演示揭示了该软设备作为现实世界中适用的应力监测的独特能力。
Stress is one of the main causes that increase the risk of serious health problems. Recent wearable devices have been used to monitor stress levels via electrodermal activities on the skin. Although many biosensors provide adequate sensing performance, they still rely on uncomfortable, partially flexible systems with rigid electronics. These devices are mounted on either fingers or palms, which hinders a continuous signal monitoring. A fully-integrated, stretchable, wireless skin-conformal bioelectronic (referred to as "SKINTRONICS") is introduced here that integrates soft, multi-layered, nanomembrane sensors and electronics for continuous and portable stress monitoring in daily life. The all-in-one SKINTRONICS is ultrathin, highly soft, and lightweight, which overall offers an ergonomic and conformal lamination on the skin. Stretchable nanomembrane electrodes and a digital temperature sensor enable highly sensitive monitoring of galvanic skin response (GSR) and temperature. A set of comprehensive signal processing, computational modeling, and experimental study provides key aspects of device design, fabrication, and optimal placing location. Simultaneous comparison with two commercial stress monitors captures the enhanced performance of SKINTRONICS in long-term wearability, minimal noise, and skin compatibility. In vivo demonstration of continuous stress monitoring in daily life reveals the unique capability of the soft device as a real-world applicable stress monitor.