Body-mass index and risk of advanced chronic kidney disease: Prospective analyses from a primary care cohort of 1.4 million adults in England
Body-mass index and risk of advanced chronic kidney disease: Prospective analyses from a primary care cohort of 1.4 million adults in England
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DOI：
10.1371/journal.pone.0173515
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发表时间：
2017-03-08
期刊：
影响因子：
3.7
通讯作者：
Woodward, Mark
中科院分区：
文献类型：
--
作者：
Herrington, William G.;Smith, Margaret;Woodward, Mark
背景尚不确定超重而非肥胖是否与晚期慢性肾病 (CKD) 相关，以及体重指数 (BMI) 与晚期 CKD 之间关联的大小和形状在不同类型的人群中有何不同。方法我们使用临床实践研究数据链记录 (2000-2014) 与英国二级护理和死亡率数据相联系，以确定至少具有一项 BMI 测量值的前瞻性队列。 Cox 模型针对年龄、性别、吸烟和社会剥夺进行了调整，并通过糖尿病、高血压和既往心血管疾病进行亚组分析，评估了 BMI 与 CKD 4-5 期和终末期肾病 (ESRD) 之间的关系。结果对 1,405,016 名 20-79 岁、平均 BMI 27.4kg/m(2) (SD 5.6) 的成年人进行了 7.5 年的随访。与 BMI 20 相比
BackgroundIt is uncertain whether being overweight, but not obese, is associated with advanced chronic kidney disease (CKD) and how the size and shape of associations between body-mass index (BMI) and advanced CKD differs among different types of people.MethodsWe used Clinical Practice Research Datalink records (2000-2014) with linkage to English secondary care and mortality data to identify a prospective cohort with at least one BMI measure. Cox models adjusted for age, sex, smoking and social deprivation and subgroup analyses by diabetes, hypertension and prior cardiovascular disease assessed relationships between BMI and CKD stages 4-5 and end-stage renal disease (ESRD).Findings1,405,016 adults aged 20-79 with mean BMI 27.4kg/m(2) (SD 5.6) were followed for 7.5 years. Compared to a BMI of 20 to