Stereoselective synthesis of the C14-C24 degraded fragment of symbiodinolide
Stereoselective synthesis of the C14-C24 degraded fragment of symbiodinolide
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DOI：
10.1016/j.tetlet.2010.03.014
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发表时间：
2010-05-12
影响因子：
1.8
通讯作者：
Uemura, Daisuke
中科院分区：
文献类型：
--
作者：
Takamura, Hiroyoshi;Kadonaga, Yuichiro;Uemura, Daisuke
Symbiodinium是一种多元醇大环内酯，于2007年从海洋甲藻Symbiodinium sp.分离出来。以cis-2-butene-1，4-diol为起始原料，立体选择性地合成了共生菌降解产物之一，具有17 R/18 R/21 R绝对构型的共生菌C1, 4-C24片段。对合成产物和降解产物的光谱数据进行详细比较，证实C14-C24片段的立体结构为17 R、18 R和21 R。(C)2010爱思唯尔有限公司版权所有。
Symbiodinolide is a polyol macrolide isolated from the marine dinoflagellate Symbiodinium sp. in 2007. The C14-C24 fragment of symbiodinolide possessing the 17R/18R/21R absolute configuration, which was obtained as one of the degraded products of symbiodinolide, was synthesized stereoselectively from cis-2-butene-1,4-diol. The detailed comparison of the synthetic product with the degraded product in the spectroscopic data confirmed that the stereostructure of the C14-C24 fragment was 17R, 18R, and 21R. (C) 2010 Elsevier Ltd. All rights reserved.