Human fetal behaviour and maternal cocaine use: a longitudinal study.
Human fetal behaviour and maternal cocaine use: a longitudinal study.
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人类胎儿行为和母亲可卡因使用：一项纵向研究。
作者：
P. Hepper
本文报告了一系列超声观察人类胎儿从孕龄21周，每隔两周到足月。母亲在孕龄18周之前一直使用可卡因，但在此年龄之后，仅在孕龄31周时使用过一次可卡因。将该胎儿的行为与一组10个未接触可卡因的相似年龄胎儿进行比较。接触可卡因导致长时间的不活动，其间穿插着一般活动增加和惊吓次数增加的时期。这在接触可卡因后立即表现得特别明显，但随着母亲停止使用可卡因，行为似乎变得更加正常。可卡因暴露胎儿的行为状态与未暴露胎儿不同。在状态1F和4F中花费的时间较长，而在状态2F中花费的时间较少。此外，没有观察到状态的时期的发生率要高得多。这些观察结果表明，母体使用可卡因会破坏胎儿的行为，表明对CNS有直接影响。产前行为观察的价值，以评估神经毒性剂的影响被证明。
This paper reports a series of ultrasound observations on a human fetus from 21 weeks of gestational age at two weekly intervals to term. The mother, until 18 weeks of gestational age, was a user of cocaine but after this age used cocaine only once at 31 weeks gestation. The behaviour of this fetus was compared to a group of 10 similar aged fetuses who were not exposed to cocaine. Exposure to cocaine resulted in prolonged periods of inactivity interspersed with periods of increased general activity and an increased number of startles. This was particularly evident immediately following exposure to cocaine but behaviour appeared to become more normal with time as the mother stopped using cocaine. The behavioural states of the cocaine exposed fetus were different from unexposed fetuses. Longer periods were spent in States 1F and 4F and less time in State 2F. Furthermore the incidence of periods where no states were observed was considerably higher. These observations demonstrate that maternal cocaine use disrupts the behaviour of the fetus indicating a direct effect on the CNS. The value of prenatal behavioural observations to assess the effects of neurotoxic agents is demonstrated.