A Possible Neurophysiological Basis of Cocaine Craving

A Possible Neurophysiological Basis of Cocaine Craving
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可卡因渴望的可能神经生理学基础

DOI:
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发表时间:
1990
期刊:
影响因子:
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通讯作者:
K. Kuhn
K. Kuhn
中科院分区:
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文献类型:
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作者:
J. Halikas;K. Kuhn

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在一个开放的临床系列研究中,寻求可卡因成瘾治疗的患者报告了与卡马西平治疗相关的可卡因渴望的主观减少。我们认为,可卡因渴求可能是点燃的行为表现,在动物实验中可卡因诱导的神经元超敏感性。开放性研究中的固有困难、主观现象和药物滥用障碍患者的可靠性,要求在将该初步观察结果应用于一般临床应用时应谨慎观察。
AbstractIn an open clinical series, patients seeking treatment for cocaine addiction reported a substantial subjective reduction in cocaine craving associated with carbamazepine treatment. We suggest that cocaine craving may be the behavioral manifestation of kindling, the neuronal supersensitivity induced by cocaine in animal studies. The inherent difficulties in open studies, of subjective phenomena, and reliability of patients with substance abuse disorders, require that caution be observed in applying this preliminary observation to general clinical use.
DOI: --
发表时间: 1988-02
期刊: The Journal of clinical psychiatry
影响因子: --
作者:
Charles P. O'Brien;Childress Ar;I. Arndt;Mclellan At;G. Woody;I. Maany
通讯作者: Charles P. O'Brien;Childress Ar;I. Arndt;Mclellan At;G. Woody;I. Maany