Dynamic Magnetic Resonance Vascular Fingerprinting During Hypercapnia for Quantitative and Multiparametric Cerebrovascular Reactivity Measures.
Dynamic Magnetic Resonance Vascular Fingerprinting During Hypercapnia for Quantitative and Multiparametric Cerebrovascular Reactivity Measures.
复制标题
高碳酸血症期间的动态磁共振血管指纹图谱用于定量和多参数脑血管反应性测量。
DOI：
10.1109/embc40787.2023.10339967
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Fan,AudreyP
中科院分区：
文献类型：
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作者：
Wheeler,GregoryJ;Lee,QuimbyN;Fan,AudreyP
磁共振指纹（MRF）代表了一个潜在的范式转变，在MR图像采集，重建和分析使用计算生物物理建模并行图像采集。其灵活性允许通过MR血管指纹（MRvF）检查脑血管指标，并且这已经进一步扩展到每隔几秒同时产生定量脑血容量（CBV），微血管血管半径和全脑组织氧饱和度（SO2）图。这允许观察快速的生理变化，如脑血管反应性（CVR），其是血管响应于血管活性刺激而扩张的能力。在这里，我们展示了一种新的协议，其中快速，自旋和梯度回波脉冲序列允许动态，同时采集MRvF和血氧水平依赖（BOLD）的措施。通过将其与定制的高碳酸血症（5%CO2）呼吸范例相结合，我们能够显示这些定量CBV，半径和SO2参数如何响应刺激而变化，并直接将其与共定位的传统使用的BOLD CVR进行比较。我们还将这些措施与另一种传统使用的动脉自旋标记序列脑血流CVR技术进行了比较。这些成像、处理和分析技术将允许进一步调查基于BOLD和基于MRVF的度量的CVR的幅度和速率，并且使得调查能够更好地理解健康老龄化和脑血管疾病中的血管功能。以及血管性认知障碍、痴呆和阿尔茨海默病等脑血管疾病的多参数功能成像生物标志物。
Magnetic resonance fingerprinting (MRF) represents a potential paradigm shift in MR image acquisition, reconstruction, and analysis using computational biophysical modelling in parallel to image acquisition. Its flexibility allows for examination of cerebrovascular metrics through MR vascular fingerprinting (MRvF), and this has been extended even further to produce quantitative cerebral blood volume (CBV), microvascular vessel radius, and tissue oxygen saturation (SO2) maps of the whole brain simultaneously every few seconds. This allows for observation of rapid physiological changes like cerebrovascular reactivity (CVR), which is the ability of vessels to dilate in response to a vasoactive stimulus. Here we demonstrated a novel protocol in which a rapid, spin- and gradient-echo pulse sequence allowed for dynamic, and simultaneous acquisition of MRvF and blood oxygen level dependent (BOLD) measures. By combining this with a tailored hypercapnic (5% CO2) breathing paradigm we were able to show how these quantitative CBV, radius, and SO2parameters changed in response to a stimulus and directly compare those to a colocalized, traditionally used BOLD CVR. We also compared these measures to another traditionally utilized technique in cerebral blood flow CVR from an arterial spin labelling sequence. These imaging, processing, and analysis techniques will allow for further investigation into the magnitude and rate of CVR based on BOLD and MRvF-based metrics and enable investigations to better understand vascular function in healthy aging and cerebrovascular diseases.Clinical Relevance— The development of dynamic magnetic resonance vascular fingerprinting has the potential to enable rapid, quantitative, and multiparametric functional imaging biomarkers of cerebrovascular diseases like vascular cognitive impairment, dementia, and Alzheimer’s disease.