RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT
RCC2 promotes breast cancer progression through regulation of Wnt signaling and inducing EMT
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RCC2通过调节Wnt信号传导和诱导EMT促进乳腺癌进展
DOI：
10.7150/jca.36430
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发表时间：
2019-01-01
影响因子：
3.9
通讯作者：
Hu, Kaishun
中科院分区：
文献类型：
--
作者：
Chen, Zhen;Wu, Wenjing;Hu, Kaishun
染色体凝聚调节因子2（Regulator of chromosome condensation 2，RCC 2），也称为TD-60，是RCC 1家族成员，在有丝分裂中发挥重要作用。然而，RCC 2在乳腺癌中的作用仍不清楚。在这项研究中，发现RCC 2在乳腺癌中发挥致癌活性。乳腺癌组织样本显示RCC 2水平升高，高水平的RCC 2与乳腺癌患者的总体生存率低相关。RCC 2的过表达显著增强乳腺癌细胞在体外和体内的细胞增殖和迁移能力。RCC 2通过激活Wnt信号通路诱导上皮-间充质转化（EMT）。总的来说，我们的研究表明，RCC 2有助于乳腺癌的进展，并通过激活Wnt信号传导作为EMT的重要调节因子。
Regulator of chromosome condensation 2 (RCC2), also known as TD-60, is an RCC1 family member and plays an essential role in mitosis. However, the roles of RCC2 in breast cancer are still unclear. In this study, RCC2 was found to exert oncogenic activities in breast cancer. Samples of breast cancer tissue revealed an increased level of RCC2 and a high level of RCC2 was associated with poor overall survival rate of breast cancer patients. Overexpression of RCC2 significantly enhanced cell proliferation and migration abilities of breast cancer cells in vitro and in vivo. Mechanistically, RCC2 induced epithelial-mesenchymal transition (EMT) through the activation of Wnt signaling pathway. Collectively, our study indicates that RCC2 contributes to breast cancer progression and functions as an important regulator of EMT through the activation of Wnt signaling.