Biochemical responses of bone metabolism to 1,25-dihydroxyvitamin D administration in black and white women
Biochemical responses of bone metabolism to 1,25-dihydroxyvitamin D administration in black and white women
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DOI：
10.1007/s001980050292
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发表时间：
2000-01-01
影响因子：
4
通讯作者：
Lindsay, R
中科院分区：
文献类型：
--
作者：
Cosman, F;Shen, V;Lindsay, R
黑人和白色女性之间骨量的种族差异的基础尚不清楚。骨转换率较低，肾钙保存较好，对甲状旁腺激素（PTH）的敏感性降低已被提出作为解释。利用1，25-二羟维生素D [1，25（OH）（2）D]刺激，尚未在这两个种族群体之间进行成骨细胞功能的动态比较。我们比较了匹配良好的黑人（n = 15）和白色（n = 15）绝经前妇女，在5天的1，25（OH）（2）D给药（1.0 μ g/天）之前和期间，以评估骨代谢的动态指标。正如预期的那样，在基线时，黑人妇女血清25-羟基维生素D和骨转换生化标志物水平较低，PTH水平略高。在基线时，黑人女性也比白色女性具有上级肾钙保存。作为对1，25（OH）（2）D给药的反应，黑人妇女血清钙的增加略大，PTH的减少更大。此外，黑人女性尿钙增量小于白色女性，骨形成骨钙素和前胶原羧基末端前肽两个标志物的增量大于白色女性。在1，25（OH）（2）D给药后，两个种族的骨吸收指数没有变化。这些数据提供了初步证据，表明黑人女性在静态和动态条件下更有效地保存钙，并且似乎比白色女性具有更好的成骨细胞功能储备。
The basis for the racial difference in bone mass between black and white women is not known. Lower bone turnover, better renal calcium conservation, and decreased sensitivity to parathyroid hormone (PTH) have been proposed as explanations. A dynamic comparison of osteoblast function, utilizing stimulation by 1,25-dihydroxyvitamin D [1,25(OH)(2)D], has not been tested between these two ethnic groups. We compared well-matched black (n = 15) and white (n = 15) premenopausal women, before and during 5 days of 1,25(OH)(2)D administration (1.0 mu g/day) in order to assess dynamic indices of bone metabolism. As expected, at baseline, black women had lower levels of serum 25-hydroxyvitamin D and biochemical markers of bone turnover with slightly higher levels of PTH. Black women also had superior renal calcium conservation than white women at baseline. In response to 1,25(OH)(2)D administration, black women had a slightly greater increase in serum calcium and greater decrement in PTH. Moreover, black women showed a lesser increment in urinary calcium than white women and a more robust increase in two markers of bone formation osteocalcin and carboxyterminal propeptide of type procollagen - than white women. There were no changes in bone resorption indices in either race upon 1,25(OH)(2)D administration, These data provide preliminary evidence that black women conserve calcium more efficiently under both static and dynamic conditions, and also appear to have better osteoblastic functional reserve than white women.