Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005
Frequency of epileptiform EEG abnormalities in a sequential screening of autistic patients with no known clinical epilepsy from 1996 to 2005
复制标题
DOI：
10.1016/j.yebeh.2005.11.001
复制
发表时间：
2006-02-01
影响因子：
2.6
通讯作者：
Schwartz, A
中科院分区：
文献类型：
--
作者：
Chez, MG;Chang, M;Schwartz, A
自闭症谱系障碍（ASD）影响166名新生儿中的1名。虽然脑电图（EEG）异常和临床癫痫发作可能在ASD中起作用，但在没有临床癫痫发作或先前异常EEG的ASD人群中EEG异常的确切频率尚不清楚。目前对EEG异常的治疗是否会影响发育尚无共识。这项对1996年至2005年期间就诊的889例ASD患者（无已知遗传疾病、脑畸形、既往用药或临床癫痫发作）的24小时动态数字EEG数据进行的回顾性审查显示，889例受试者中有540例（60.7%）在睡眠中存在异常EEG癫痫样活动，基于临床回归无差异。癫痫样异常最常见的部位位于右颞区。在176例接受丙戊酸治疗的患者中，80例EEG正常化，30例EEG与首次EEG相比改善（重复EEG平均10.1个月）。(c)2005年爱思唯尔公司All rights reserved.
Autism spectrum disorders (ASDs) affect 1 in 166 births. Although electroencephalogram (EEG) abnormalities and clinical seizures may play a role in ASDs, the exact frequency of EEG abnormalities in an ASD population that has not had clinical seizures or prior abnormal EEGs is unknown. There is no current consensus on whether treatment of EEG abnormalities may influence development. This retrospective review of 24-hour ambulatory digital EEG data collected from 889 ASD patients presenting between 1996 and 2005 (with no known genetic conditions, brain malformations, prior medications, or clinical seizures) shows that 540 of 889 (60.7%) subjects had abnormal EEG epileptiform activity in sleep with no difference based on clinical regression. The most frequent sites of epileptiform abnormalities were localized over the right temporal region. Of 176 patients treated with valproic acid, 80 normalized on EEG and 30 more showed EEG improvement compared with the first EEG (average of 10.1 months to repeat EEG). (c) 2005 Elsevier Inc. All rights reserved.