A Selective Single Step Amidation of Polyfluoroarenes.
A Selective Single Step Amidation of Polyfluoroarenes.
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多氟芳烃的选择性一步酰胺化。
DOI：
10.1016/j.jfluchem.2021.109821
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发表时间：
2021
影响因子：
1.9
通讯作者：
Weaver,JimmieD
中科院分区：
文献类型：
--
作者：
Noel,AlyssaM;Hamilton,Matthew;Keen,Brockton;Despain,Megan;Day,Jon;Weaver,JimmieD
本化学建立了一种利用亲核芳香族取代合成全氟芳酰和聚氟芳酰酰胺的方法。传统上，这种酰胺是通过两步过程构建的，即氨解和n -酰化。在温和的反应条件下，一步制得n -聚氟芳基酸酰胺。获得最佳产率的关键是使用两种等效的亲核试剂。此外，还讨论了反应的机理，这对其他相关的亲核取代反应具有指导意义。
This chemistry establishes a method for the synthesis of per- and poly-fluoroaryl acid amides, utilizing nucleophilic aromatic substitution. Traditionally, such amides are constructed in a two-step process, namely, ammonolysis and thenN-acylation. Herein, good yields ofN-polyfluoroaryl acid amides were achieved in a single step under mild reaction conditions. Key to achieving optimal yields is the use of two equivalents of the nucleophile. In addition, the mechanism of the reaction is discussed which has implications for other related nucleophilic substitutions.