The morphologic spectrum of primary cutaneous anaplastic large T-cell lymphoma: a histopathologic study on 66 biopsy specimens from 47 patients with report of rare variants
The morphologic spectrum of primary cutaneous anaplastic large T-cell lymphoma: a histopathologic study on 66 biopsy specimens from 47 patients with report of rare variants
复制标题
DOI：
10.1111/j.1600-0560.2007.00778.x
复制
发表时间：
2008-01-01
影响因子：
1.7
通讯作者：
Cerroni, Lorenzo
中科院分区：
文献类型：
--
作者：
Massone, Cesare;El-Shabrawi-Caelen, Laila;Cerroni, Lorenzo
背景：原发性皮肤间变性大T细胞淋巴瘤(PCALCL)是一种定义明确的实体，其预后有别于结节性间变性大细胞淋巴瘤(NALCL)。NALCL的几种组织学变异体(常见的、淋巴组织细胞的和小细胞的)已经被表征。方法：回顾分析47例(男：女，27：20；中位年龄：53岁；平均年龄：51.8岁；范围：14~82岁)66例PCALCL的临床病理特征，以更好地描述PCALCL的临床特征。与NALCL相比，在PCALCL中，更常见的是明显的反应性浸润物。实际上，26例被分为炎症型(15例)和淋巴组织细胞型(11例)。在主要细胞形态方面，大型间变性细胞(33%)几乎与大型多形性细胞(36%)和中小型细胞(26%)一样多见。我们首次在皮肤中报告了2例罕见的病例，以大细胞为主，外观呈“印章环”样。结论：PCALCL具有多种多样的组织病理学表现和广泛的细胞形态特征。
Background: Primary cutaneous anaplastic large T-cell lymphoma (PCALCL) is a well-defined entity with prognostic differences from the nodal counterpart [nodal anaplastic large cell lymphoma (NALCL)]. Several histological variants of NALCL have been characterized (common, lymphohistiocytic and small cell). However, studies on morphological variants of PCALCLs are lacking.Methods: We analyzed retrospectively the clinicopathologic features of 66 biopsies from 47 patients (M : F = 27 : 20; median age: 53 years; mean age: 51.8 years; range: 14-82) with PCALCL, in order to better characterize the spectrum of this unusual neoplasm.Results: The 'common variant' was the most frequent (40.4%). In contrast to NALCL, in PCALCL, marked reactive infiltrates are more commonly present. In fact, 26 cases were classified as 'inflammatory type' (15 cases) and 'lymphohistiocytic' (11 cases). Concerning the predominant cell morphology, large anaplastic cells (33%) were almost as frequent as large pleomorphic (36%) and small to medium-sized cells (26%). We reported for the first time in the skin 2 rare cases with the predominance of large cells with a 'signet-ring'-like appearance. Epidermotropism and presence of eosinophils were found in a proportion of cases in all PCALCL variants.Conclusions: PCALCL is characterized by variable histopathological presentations and a broad cytomorphologic spectrum.