Modulation of the length of the cell cycle time of MCF-7 human breast cancer cells by melatonin
Modulation of the length of the cell cycle time of MCF-7 human breast cancer cells by melatonin
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DOI：
10.1016/0024-3205(95)02359-3
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发表时间：
1996-01-26
期刊：
影响因子：
6.1
通讯作者：
SanchezBarcelo, EJ
中科院分区：
文献类型：
--
作者：
Cos, S;Recio, J;SanchezBarcelo, EJ
已经显示褪黑激素对培养物中的MCF-7人乳腺癌细胞的增殖具有直接抑制作用。在本工作中，vie研究了褪黑素是否增加MCF-7细胞的细胞周期长度。在部分同步化并用[H-3]胸苷标记的MCF-7细胞中，加入褪黑素（10（-9）M），标记指数节律的周期从20.36小时移动到23.48小时。褪黑激素显著增加（p < 0.005）人乳腺癌细胞的细胞周期持续时间的事实支持了这种激素通过细胞周期特异性机制通过延迟MCF-7细胞进入有丝分裂来发挥其部分抗肿瘤作用的观点。
It has been shown that melatonin has a direct inhibitory effect on the proliferation of MCF-7 human breast cancer cells in culture. In the present work, vie studied whether the length of the cell cycle of MCF-7 cells is increased by melatonin. In MCF-7 cells partially synchronized and labelled with [H-3]thymidine, melatonin (10(-9) M), added to the culture medium, shifted the period of the labeling index rhythm from 20.36 hours to 23.48 hours. The fact that melatonin significantly increased (p < 0.005) the duration of the cell cycle of human breast cancer cells, support the notion that this hormone exerts part of its antitumor effect through a cell-cycle-specific mechanism by delaying the entry of MCF-7 cells into mitosis.