Multimodal Sensory Responses of Nucleus Reticularis Gigantocellularis and the Responses' Relation to Cortical and Motor Activation
Multimodal Sensory Responses of Nucleus Reticularis Gigantocellularis and the Responses' Relation to Cortical and Motor Activation
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DOI：
10.1152/jn.01122.2009
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发表时间：
2010-05-01
影响因子：
2.5
通讯作者：
Pfaff, Donald
中科院分区：
文献类型：
--
作者：
Martin, Eugene M.;Pavlides, Constantine;Pfaff, Donald
马丁·EM，Pavlides C，Pfaff D.巨细胞网状核的多模式感觉反应及其与皮质和运动激活的关系。《神经生理学杂志》103：2326-2338,2010。2010年2月24日首次出版；DOI：10.1152/jn.01122.2009。延髓网状结构中网状巨细胞核(NRGc)的大神经元的连接可能允许以多种方式整合需要立即采取行动的刺激，并协调激活皮质和运动活动。我们同步记录了自由、非麻醉大鼠延髓NRGc神经元的皮层局部场电位、颈部肌肉肌电(EMG)和神经活动，以确定NRGc的活动是否与全身觉醒的调制一致。我们观察了单个NRGc神经元对所有测试方式的兴奋反应：触觉、视觉、听觉、前庭和嗅觉。兴奋与颈部肌肉肌电幅度的增加直接相关，并与皮层活动的快速振荡(30-80赫兹)的功率增加和慢速振荡(2-8赫兹)的功率降低相对应。由于这些网状结构神经元可以对大范围的刺激做出反应，与行为反应的启动相关的放电频率增加，我们推测它们是基本的“第一反应者”中枢神经系统唤醒机制的一部分。
Martin EM, Pavlides C, Pfaff D. Multimodal sensory responses of nucleus reticularis gigantocellularis and the responses' relation to cortical and motor activation. J Neurophysiol 103: 2326-2338, 2010. First published February 24, 2010; doi: 10.1152/jn.01122.2009. The connectivity of large neurons of the nucleus reticularis gigantocellularis (NRGc) in the medullary reticular formation potentially allows both for the integration of stimuli, in several modalities, that would demand immediate action, and for coordinated activation of cortical and motoric activity. We have simultaneously recorded cortical local field potentials, neck muscle electromyograph (EMG), and the neural activity of medullary NRGc neurons in unrestrained, unanesthetized rats to determine whether the activity of the NRGc is consistent with the modulation of general arousal. We observed excitatory responses of individual NRGc neurons to all modalities tested: tactile, visual, auditory, vestibular, and olfactory. Excitation was directly linked to increases in neck muscle EMG amplitude and corresponded with increases in the power of fast oscillations (30 to 80 Hz) of cortical activity and decreases in the power of slow oscillations (2 to 8 Hz). Because these reticular formation neurons can respond to broad ranges of stimuli with increased firing rates associated with the initiation of behavioral responses, we infer that they are part of an elementary "first responder" CNS arousal mechanism.