Correlation between transcranial Doppler ultrasonography and regional cerebral blood flow in experimental intracranial hypertension
Correlation between transcranial Doppler ultrasonography and regional cerebral blood flow in experimental intracranial hypertension
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DOI：
10.1161/01.str.28.3.603
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发表时间：
1997-03-01
期刊：
影响因子：
8.3
通讯作者：
Takaya, M
中科院分区：
文献类型：
--
作者：
Nagai, H;Moritake, K;Takaya, M
背景与目的经颅多普勒超声（TCD）可在颅内压升高的情况下提供脑循环的有用信息。本研究的目的是评估脑血流（CBF）和TCD参数之间的相关性的条件下的边界颅内压增高，可以导致braindeath.Methods猫的幕上硬膜外球囊膨胀颅内压升高。结果在本研究中，观察到4种特征性血流模式，其出现顺序为：尖波、收缩期血流、收缩期峰电位和无血流。这些血流模式与血流速度、CBF、脉动指数和脑灌注压显著相关。结论多普勒超声可检测脑循环的临界水平，提示TCD可作为脑死亡患者脑循环骤停的一种评估工具。
Background and Purpose Transcranial Doppler ultrasonography (TCD) provides useful information on cerebral circulation even under raised intracranial pressure. This study was designed to evaluate the correlation between cerebral blood flow (CBF) and TCD parameters under conditions of boundary intracranial hypertension that can cause brain death.Methods Intracranial pressure was raised by inflation of a supratentorial epidural balloon in cats. Blood flow velocity of the middle cerebral artery was measured transorbitally with microvascular Doppler sonography, and intracranial pressure and CBF were evaluated.Results In this study, four characteristic flow patterns were observed, appearing in the following order with progressive increases in intracranial pressure: sharp wave, systolic flow, systolic spike, and no flow. These flow patterns showed a significant correlation with flow velocity, CBF, the pulsatility index, and cerebral perfusion pressure. The systolic-spike and no-flow patterns and pulsatility index over 4.0 indicated decreased CBF, under 10% of control values.Conclusions The critical level of brain circulation can be detected by Doppler sonography, indicating that TCD is available as a tool for the assessment of cerebral circulatory arrest in brain death.