When Is the Hippocampus Involved in Recognition Memory?
When Is the Hippocampus Involved in Recognition Memory?
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DOI：
10.1523/jneurosci.6413-10.2011
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发表时间：
2011-07-20
影响因子：
5.3
通讯作者：
Warburton, Elizabeth C.
中科院分区：
文献类型：
--
作者：
Barker, Gareth R. I.;Warburton, Elizabeth C.
海马体在识别记忆中的作用是有争议的。识别记忆的判断可以使用不同类型的信息，包括物体熟悉度，物体的空间位置，或何时遇到物体。实验1研究了海马在识别记忆任务中的作用，这些任务要求动物使用这些不同类型的记忆信息。在海马或嗅周或前额叶皮层双侧细胞毒性病变的大鼠进行了测试，电池的自发对象识别任务，要求动物作出识别记忆判断，使用熟悉（新的对象偏好），对象的位置信息（对象的位置记忆），或近因信息（时间顺序记忆）。实验2研究了当使用不同类型的再认记忆信息时，海马是否与嗅周皮层或前额叶皮层相互作用。因此，制备了海马中单侧细胞毒性损伤与对侧嗅周或前额叶皮质中损伤相结合的大鼠组。然后对大鼠进行一系列物体识别记忆任务的测试。实验一发现，海马在物体定位、物体就位和近因再认记忆中起关键作用，但在新物体偏好任务中不起作用。实验2表明，物体到位和近因识别记忆的表现取决于海马和嗅周或内侧前额叶皮质之间的功能相互作用。因此，海马体在识别记忆中起作用，当这种记忆涉及记住在特定地方发生的特定刺激时，或者当记忆包含时间或物体近因成分时。
The role of the hippocampus in recognition memory is controversial. Recognition memory judgments may be made using different types of information, including object familiarity, an object's spatial location, or when an object was encountered. Experiment 1 examined the role of the hippocampus in recognition memory tasks that required the animals to use these different types of mnemonic information. Rats with bilateral cytotoxic lesions in the hippocampus or perirhinal or prefrontal cortex were tested on a battery of spontaneous object recognition tasks requiring the animals to make recognition memory judgments using familiarity (novel object preference); object-place information (object-in-place memory), or recency information (temporal order memory). Experiment 2 examined whether, when using different types of recognition memory information, the hippocampus interacts with either the perirhinal or prefrontal cortex. Thus, groups of rats were prepared with a unilateral cytotoxic lesion in the hippocampus combined with a lesion in either the contralateral perirhinal or prefrontal cortex. Rats were then tested in a series of object recognition memory tasks. Experiment 1 revealed that the hippocampus was crucial for object location, object-in-place, and recency recognition memory, but not for the novel object preference task. Experiment 2 revealed that object-in-place and recency recognition memory performance depended on a functional interaction between the hippocampus and either the perirhinal or medial prefrontal cortices. Thus, the hippocampus plays a role in recognition memory when such memory involves remembering that a particular stimulus occurred in a particular place or when the memory contains a temporal or object recency component.