Global Tuberculosis Report 2020 - Reflections on the Global TB burden, treatment and prevention efforts.
Global Tuberculosis Report 2020 - Reflections on the Global TB burden, treatment and prevention efforts.
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DOI：
10.1016/j.ijid.2021.02.107
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发表时间：
2021-12
期刊：
影响因子：
--
通讯作者：
Zumla A
中科院分区：
文献类型：
--
作者：
Chakaya J;Khan M;Ntoumi F;Aklillu E;Fatima R;Mwaba P;Kapata N;Mfinanga S;Hasnain SE;Katoto PDMC;Bulabula ANH;Sam-Agudu NA;Nachega JB;Tiberi S;McHugh TD;Abubakar I;Zumla A
《2020年10月全球结核病报告》回顾了2018年9月在纽约举行的联合国大会结核病问题高级别会议上的政治宣言中设定的结核病控制战略和联合国(UN)目标。结核病护理和预防方面的进展非常缓慢。2019年，结核病仍然是单一感染病原体导致的最常见死亡原因。在全球范围内，2019年估计有1000万人患上结核病，艾滋病毒阴性者中估计有120万人死于结核病，艾滋病毒携带者中又有20.8万人死于结核病。成人占88%，儿童占12%。世卫组织东南亚(44%)、非洲(25%)和西太平洋(18%)地区的结核病患者最多。8个国家占全球总数的三分之二：印度(26%)、印度尼西亚(8.5%)、中国(8.4%)、菲律宾(6.0%)、巴基斯坦(5.7%)、尼日利亚(4.4%)、孟加拉国(3.6%)和南非(3.6%)。在350万儿童结核病治疗五年计划中，只有30%实现了目标。主要的进展是开发了治疗MDRTB的新的全口服方案和预防治疗的新方案。2020年，新冠肺炎大流行取代结核病成为全球最大的传染病死亡原因。值得注意的是，甚至在新冠肺炎大流行到来之前，全球结核病控制工作就没有步入正轨。改善次优的结核病治疗和预防服务仍然存在许多挑战。结核病筛查和诊断检测服务需要加强。结核病的主要驱动因素仍然是营养不良、贫困、糖尿病、吸烟和家庭空气污染，需要解决这些问题，以实现世卫组织2035年结核病护理和预防目标。国家项目需要包括结核病后整体福祉的干预措施。自首次发现新冠肺炎以来，全球的协调和政治意愿以及巨额的财政投入导致了针对SARS-CoV2感染的有效疫苗的开发。世界现在同样需要关注利用新的技术方法开发新的结核病疫苗。
The October 2020 Global TB report reviews TB control strategies and United Nations (UN) targets set in the political declaration at the September 2018 UN General Assembly high-level meeting on TB held in New York. Progress in TB care and prevention has been very slow. In 2019, TB remained the most common cause of death from a single infectious pathogen. Globally, an estimated 10.0 million people developed TB disease in 2019, and there were an estimated 1.2 million TB deaths among HIV-negative people and an additional 208, 000 deaths among people living with HIV. Adults accounted for 88% and children for 12% of people with TB. The WHO regions of South-East Asia (44%), Africa (25%), and the Western Pacific (18%) had the most people with TB. Eight countries accounted for two thirds of the global total: India (26%), Indonesia (8.5%), China (8.4%), the Philippines (6.0%), Pakistan (5.7%), Nigeria (4.4%), Bangladesh (3.6%) and South Africa (3.6%). Only 30% of the 3.5 million five-year target for children treated for TB was met. Major advances have been development of new all oral regimens for MDRTB and new regimens for preventive therapy. In 2020, the COVID-19 pandemic dislodged TB from the top infectious disease cause of mortality globally. Notably, global TB control efforts were not on track even before the advent of the COVID-19 pandemic. Many challenges remain to improve sub-optimal TB treatment and prevention services. Tuberculosis screening and diagnostic test services need to be ramped up. The major drivers of TB remain undernutrition, poverty, diabetes, tobacco smoking, and household air pollution and these need be addressed to achieve the WHO 2035 TB care and prevention targets. National programs need to include interventions for post-tuberculosis holistic wellbeing. From first detection of COVID-19 global coordination and political will with huge financial investments have led to the development of effective vaccines against SARS-CoV2 infection. The world now needs to similarly focus on development of new vaccines for TB utilizing new technological methods.
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影响因子：
11.8
作者：
Bulabula, Andre N. H.;Nelson, Jenne A.;Nachega, Jean B.
通讯作者：
Nachega, Jean B.
DOI：
10.5588/ijtld.17.0706
发表时间：
2018-04-01
影响因子：
4
作者：
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影响因子：
158.5
作者：
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影响因子：
56.3
作者：
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通讯作者：
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