Transformation of sib-pair values for the Haseman-Elston method.
Transformation of sib-pair values for the Haseman-Elston method.
复制标题
Haseman-Elston 方法的同胞对值的转换。
DOI：
10.1086/320101
复制
发表时间：
2001
影响因子：
9.8
通讯作者：
Wright,FA
中科院分区：
文献类型：
--
作者：
Wang,D;Lin,S;Cheng,R;Gao,X;Wright,FA
The squared sib-pair phenotype difference (SQD) has been used as a dependent variable in the Haseman-Elston (H-E) regression quantitative-trait locus (QTL) linkage method, but it has been shown that the SQD does not make full use of linkage information. In this study, we examine the efficiency of SQD in H-E regression compared to other proposed functions of the sib-pair phenotypes. A new function of sib-pair phenotypes, the product of pair values corrected with family mean (PCF), is shown to have desirable properties in many realistic situations. Consistent results were obtained using a combination of large-sample analytic approximations, simulation, and analyses of quantitative-trait data from Genetic Analysis Workshop 10. The advantages of PCF are further improved in the presence of family-specific effects arising from environmental factors or when additional QTLs influence the trait. All of the phenotype functions are incorporated in our new, freely available linkage-mapping program MULTIGENE 1.0 for the PC environment.
