Chronological analysis of physiological t2*signal IF change in the cerebrum during breath holding
Chronological analysis of physiological t2*signal IF change in the cerebrum during breath holding
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DOI：
10.1002/jmri.1049
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发表时间：
2001-03-01
影响因子：
4.4
通讯作者：
Yoshida, S
中科院分区：
文献类型：
--
作者：
Nakada, K;Yoshida, D;Yoshida, S
本研究的目的是检查哪些生理因素影响正常志愿者屏气（BH）（吸气后呼吸暂停和呼气后呼吸）期间大脑T2* 信号强度（SI）。我们检查了缺氧气体吸入、呼吸运动和BH引起的SI变化。高速平面回波图像（EPI）显示SI的变化，可分为五个阶段。报告表明，由BH引起的SI变化是由于对脱氧血红蛋白（脱氧血红蛋白（dHb））的磁化率和高碳酸血症的影响，但这些报告不能完全解释所观察到的五个阶段。除了脱氧血红蛋白敏感性和高碳酸血症外，我们发现呼吸运动通过影响流入感兴趣区域（ROI）的血流（根据右颈动脉血流判断）在修改SI中发挥第三个关键作用。因此，我们建议BH引起的生理SI变化来自血氧，高碳酸血症和呼吸运动。(C)2001 Wiley-Liss，Inc.
The purpose of this study was to examine which physiological factors affect cerebral T2* signal intensity (SI) during breath holding (BH) (apnea after Inspiration and breathing after expiration) in normal volunteers. We examined SI changes caused by anoxic gas inhalation, by respiratory movements, and by BH. High-speed. echo planar images (EPI) showed changes In SI that could be divided into five phases. Reports indicate that SI changes induced by BH are due to the effects on the magnetic susceptibility of deoxygenated hemoglobin (deoxyhemoglobin (dHb)) and to hypercapnia, but these reports could not fully explain the observed five phases. In addition to deoxyhemoglobin susceptibility and hypercapnia, we found that respiratory movements play a third critical role In modifying SI by affecting blood flow Into the region of interest (ROI), as judged from right carotid artery flow. Consequently, we propose that the physiological SI changes induced by BH are derived from blood oxygenation, hypercapnia, and respiratory movements. (C) 2001 Wiley-Liss, Inc.