INCREASED APOLIPOPROTEIN-A-IV IN RAT MESENTERIC LYMPH AFTER LIPID MEAL ACTS AS A PHYSIOLOGICAL SIGNAL FOR SATIATION
INCREASED APOLIPOPROTEIN-A-IV IN RAT MESENTERIC LYMPH AFTER LIPID MEAL ACTS AS A PHYSIOLOGICAL SIGNAL FOR SATIATION
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DOI：
10.1152/ajpgi.1992.262.6.g1002
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发表时间：
1992-06-01
影响因子：
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通讯作者：
TSO, P
中科院分区：
文献类型：
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作者：
FUJIMOTO, K;CARDELLI, JA;TSO, P
脂质餐后，肠系膜淋巴中乳糜微粒运输和载脂蛋白a - iv （apo a - iv）的输出显著增加。脂质输注后淋巴瘘大鼠肠系膜淋巴经右心房导管长期留置给药后对禁食24 h的大鼠有厌食作用。脂质输注前的淋巴和饲喂脂质加Pluronic L-81（一种有效的乳糜微粒形成抑制剂）的大鼠的淋巴没有厌食作用。单特异性抗体特异性沉淀载脂蛋白a - iv后，乳糜微粒和富含载脂蛋白a - iv的淋巴失去了其厌食作用。脂质餐后6-8小时，静脉输注与乳糜淋巴中相同量的纯化载脂蛋白a - iv可抑制食物摄入。载脂蛋白A-I不具有载脂蛋白A-IV的这种独特生理功能。有人提出，载脂蛋白a - iv是一种循环信号释放响应脂肪喂养，并可能介导厌食的脂质餐的作用。
Chylomicron transport and apolipoprotein A-IV (apo A-IV) output in mesenteric lymph increases significantly after a lipid meal. Mesenteric lymph collected from lymph-fistula rats after lipid infusion exerted an anorectic effect on 24 h fasted rats after administration through chronically indwelling right atrial catheter. Lymph before lipid infusion and lymph collected from a rat fed lipid plus Pluronic L-81 (a potent inhibitor of chylomicron formation) had no anorectic effect. Chylomicron and apo A-IV-rich lymph lost its anorectic effect after specific immunoprecipitation of apo A-IV by a monospecific antibody. Intravenous infusion of the same amount of purified apo A-IV as in chylous lymph 6-8 h after a lipid meal suppressed food intake. This unique physiological function of apo A-IV is not shared by apolipoprotein A-I. It is proposed that apo A-IV is a circulating signal released in response to fat feeding and that it is likely to mediate the anorectic effect of a lipid meal.