Inheritance of human α1-acid glycoprotein (orosomucoid) variants
Inheritance of human α1-acid glycoprotein (orosomucoid) variants
复制标题
人类 α1-酸性糖蛋白（orosumucoid）变体的遗传
DOI：
10.1172/jci106195
复制
发表时间：
1969
影响因子：
15.9
通讯作者：
A. Alper
中科院分区：
文献类型：
--
作者：
A. Johnson;Karl ScHMW;CHEsum;A. Alper
摘要
虽然在人类中已经描述了无唾液酸α1-酸性糖蛋白的变体，但这些类型的遗传方式以前尚未报道。本研究采用神经氨酸酶处理的全血清琼脂糖凝胶电泳后免疫固定的新技术，证明家系成员中α1-酸性糖蛋白变异体的类型与常染色体共显性遗传特征一致。基因频率已经确定了几个种族群体。在总共11对母胎-脐带血清中，有7对是不一致的类型，表明胎儿合成α1-酸性糖蛋白，并证实了先前的报告，即该蛋白没有显著的经胎盘通过。
Abstract
Although variants of sialic acid-free α1-acid glycoprotein have been described in human beings, the mode of inheritance of these types has not been reported previously. With the use of a new technique of immunofixation after agarose gel electrophoresis of neuraminidase-treated whole serum, the present study demonstrates that the types of α1-acid glycoprotein variants in family members are consistent with inheritance as autosomal traits with codominant expression. Gene frequencies have been determined for several ethnic groups. Of a total of 11 maternal-cord serum pairs, seven were discordant types, indicating that the fetus synthesizes α1-acid glycoprotein and confirming a previous report that there is no significant transplacental passage of this protein.