Sperm Interaction with the Female Reproductive Tract
Sperm Interaction with the Female Reproductive Tract
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DOI：
10.1111/j.1439-0531.2012.02097.x
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发表时间：
2012-08-01
影响因子：
1.7
通讯作者：
Druart, X.
中科院分区：
文献类型：
--
作者：
Druart, X.
精子在女性体内的传递是受精成功的关键。从它们在阴道中的沉积到最终在输卵管中的迁移，精子通过生殖道的不同区域，在那里它们遇到不同的环境。根据物种的不同，宫颈和子宫输卵管连接部(UTJ)是两个相对重要性不同的屏障。在发情周期中，宫颈粘液的蛋白质组成、糖化程度和水合作用都会发生变化。几种精子表面蛋白与它们通过宫颈粘液和UTJ的迁移有关。回顾了有关精子在精子转运过程中与女性生殖道不同隔室内的上皮组织分泌物相互作用的资料，特别强调了精子通过宫颈的迁移。
Sperm transit in the female tract is a critical event for the success of fertilization. From their deposition in the vagina to final migration in the oviduct, sperm pass through the different compartments of the genital tract in which they encounter different environments. The cervix and the uterotubal junction (UTJ) are two barriers with different relative importance according to the species. The protein composition, the degree of glycosylation and the hydration of the cervical mucus change during the oestrous cycle. Several sperm surface proteins are associated with their migration through the cervical mucus and the UTJ. Data regarding the interaction of sperm with secretions of the epithelial tissue lining the different compartments of the female genital tract during the sperm transit are reviewed, with a particular emphasis on the migration of sperm through the cervix.