Concordance in pathological response to neoadjuvant chemotherapy between invasive and noninvasive components of primary breast carcinomas.
Concordance in pathological response to neoadjuvant chemotherapy between invasive and noninvasive components of primary breast carcinomas.
复制标题
DOI：
10.1007/bf02967551
复制
发表时间：
2002-01-01
期刊：
影响因子：
--
通讯作者：
Akashi-Tanaka, Sadako
中科院分区：
文献类型：
--
作者：
Matsuo, Kaneyuki;Fukutomi, Takashi;Akashi-Tanaka, Sadako
背景技术背景：浸润性乳腺癌是由侵入性和非侵入性成分在不同的比例，有时两个组件显示不同的组织病理学反应化疗，但一直没有研究，迄今比较病理学反应化疗的侵入性和非侵入性components.Patients和方法：一个连续系列的100名妇女新辅助化疗阿霉素和多西他赛每三周手术前。化疗后，手术切除标本进行组织学研究，根据日本乳腺癌Society.Results的标准：5例（5/100; 5%）被确定为显示3级病理反应，28例（28/100; 28%）显示2级反应。有6例3级（6/96; 6%）和18例2级（18/96; 19%）侵入性组件病例。7例3级（7/82; 9%）和18例2级（18/82; 22%）病例显示无创组件的病理学反应。在病理反应方面，侵袭性和非侵袭性成分之间有很强的相关性（p
BACKGROUND: Invasive breast carcinomas are composed of invasive and noninvasive components in varying proportions and sometimes the two components show different histopathological responses to chemotherapy, however there has been no study as yet comparing the pathological response to chemotherapy of invasive and noninvasive components.PATIENTS AND METHODS: A consecutive series of 100 women neoadjuvant chemotherapy with doxorubicin and docetaxel every three weeks before surgery. After the chemotherapy, surgically resected specimens were studied histologically according to the criteria of the Japanese Breast Cancer Society.RESULTS: Five cases (5/100; 5%) were determined to show Grade 3 pathological response, and 28 cases (28/100; 28%) showed Grade 2 response. There were 6 Grade 3 (6/96; 6%) and 18 Grade 2 (18/96; 19%) invasive component cases. There were 7 Grade 3 (7/82; 9%) and 18 Grade 2 (18/82; 22%) cases showing pathological response in the noninvasive component. With regard to pathological response, there was a strong correlation between the invasive and noninvasive components (p