Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver.
Evaluation of the effects of L-carnitine on medaka (Oryzias latipes) fatty liver.
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DOI：
10.1038/s41598-017-02924-5
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发表时间：
2017-06-05
影响因子：
4.6
通讯作者：
Sakaida I
中科院分区：
文献类型：
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作者：
Fujisawa K;Takami T;Matsuzaki A;Matsumoto T;Yamamoto N;Terai S;Sakaida I
近年来，与生活方式相关的疾病已成为一个主要问题。脂肪肝发病率的增加凸显了非酒精性脂肪肝病（NAFLD）和非酒精性脂肪性肝炎（NASH）问题亟待解决。左旋肉碱是一种已知可将脂肪酸转运至线粒体以增强 β-氧化介导的脂肪代谢的化合物。在本研究中，分析了左旋肉碱给药对青鳉（Oryzias latipes）脂肪肝的影响，以检查疾病的改善和代谢变化。此外，还研究了同时服用左旋肉碱和二十碳五烯酸 (20:5n-3) (EPA) 的效果。研究结果表明，脂质沉积减少，与β-氧化相关的代谢物增加，肝脏脂肪酸水平显着降低，这意味着脂肪肝状况得到改善。同时服用左旋肉碱和 EPA 通过改变青鳉脂肪肝模型中的脂肪酸组成产生了进一步的益处。
Lifestyle-related diseases have become a major issue in recent years. The increasing incidence of fatty liver underlines the urgency with which the issues of non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) need to be addressed. L-carnitine is a compound known to transport fatty acids into the mitochondria to enhance β-oxidation-mediated metabolism of fats. In this study, the effects of L-carnitine administration on fatty liver of medaka (Oryzias latipes) were analysed, to check for disease improvement and metabolic changes. Additionally, the effects of the concomitant administration of L-carnitine and eicosapentaenoic acid (20:5n-3) (EPA) were investigated. Findings indicated reduced lipid deposition, increase in metabolites associated with β-oxidation, and significant reduction in fatty acid levels in the liver, implying improvement in fatty liver condition. Concomitant administration of L-carnitine and EPA resulted in further benefits, via changes in fatty acid composition in the medaka fatty liver model.