Personality and Depression in Parkinson's Disease
Personality and Depression in Parkinson's Disease
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帕金森病的人格与抑郁
DOI：
--
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发表时间：
1993
影响因子：
1.9
通讯作者：
W. Roller
中科院分区：
文献类型：
--
作者：
J. Hubble;R. Venkatesh;R. Hassanein;C. Gray;W. Roller
帕金森氏症（PD）患者的特点是具有鲜明的个性和内向的特征。这些人格特征据说早于运动症状，并被理论化为潜在PD的微妙线索。为了验证这一假设，我们比较了35名PD受试者和35名对照组的远程和当前人格特征。受试者的配偶完成了一份人格量表（PI），描述了患者的发病前和当前状态。PD患者的病前PI与对照组不同，表现为更“安静”、“慷慨”、“谨慎”和“脾气平和”，而不那么“灵活”。PD受试者的当前人格特征与报告的病前人格特征有很大差异，即24项PI中有13项有显著变化。PD受试者的发病前和当前人格量表反应与抑郁症状和疾病严重程度相关。认知、烟草使用、酒精消费和农村与城市居住与PI反应无关。我们的结论是，PD患者在发病前往往被视为内向者，随着疾病的发作，更显著的个性变化被认识到。这些感知似乎与抑郁情绪密切相关，并在较小程度上与运动障碍相关
The Parkinson's disease (PD) patient has been characterized as having a distinctive personality with introverted features. These personality traits are said to predate motor symptoms and are theorized to serve as a subtle clue to latent PD. To examine this hypothesis, we compared remote and current personality features in 35 PD subjects and 35 controls. Subjects' spouses completed a personality inventory (PI) characterizing patients' premorbid and current status. The premorbid PI of PD subjects differed from that of controls in being more “quiet,” “generous,” “cautious,” and “even-tempered,” and less “flexible.” The characterization of the PD subjects' current personality differed greatly from reported premorbid personality features, i.e., significant change in 13 of 24 PI items. Personality inventory responses regarding both the PD subjects' premorbid and current personality correlated to symptoms of depression and disease severity. Cognition, tobacco use, alcohol consumption, and rural' versus urban residency did not correlate with PI responses. We conclude that PD patients are apt to be viewed as introverts premorbidly, and, with disease onset, more striking personality, changes are recognized. These perceptions appear to be closely linked to depressed affect and correlate with motor impairment to a lesser extent