Genetic analysis of human obesity in an Italian sample.
Genetic analysis of human obesity in an Italian sample.
复制标题
意大利样本中人类肥胖的遗传分析。
作者：
L. Zonta;S. Jayakar;M. Bosisio;A. Galante;V. Pennetti
对来自奥斯塔（意大利北部）的核心家庭样本进行了肥胖遗传因素的分析。这些家庭包括在初步筛查中被认为肥胖的所有小学生的父母和兄弟姐妹以及非肥胖儿童及其核心家庭的类似样本。此类家庭数量分别为67户和112户。应用了多项测试来检查遗传对肥胖的影响，特别是研究显性主基因的存在。我们的结论是，遗传因素肯定存在。一些分析表明存在一个作用较弱的显性主基因。
An analysis of the genetic factors in obesity has been carried out on a sample of nuclear families from Aosta (N. Italy). The families consisted of the parents and sibs of all elementary school children considered to be obese during a preliminary screening and a similar sample of non-obese children and their nuclear families. The numbers of such families were 67 and 112, respectively. Several tests were applied in order to examine the genetic contribution to obesity, and in particular to investigate the presence of a dominant major gene. Our conclusions are that genetic factors are certainly present. Several analyses suggest the presence of a dominant major gene with weak effect.