Dispersion of the neurons expressing layer specific markers in the reeler brain
Dispersion of the neurons expressing layer specific markers in the reeler brain
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DOI：
10.1111/j.1440-169x.2009.01153.x
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发表时间：
2010-02-01
影响因子：
2.5
通讯作者：
Katsuyama, Yu
中科院分区：
文献类型：
--
作者：
Dekimoto, Hideyuki;Terashima, Toshio;Katsuyama, Yu
具有相似功能（包括神经元连接和基因表达）的神经元在脊椎动物大脑内形成离散的浓缩结构。这在由皮质层和神经元核形成的电路中得到了例证。众所周知，Reelin 蛋白是啮齿动物和人类这些神经元结构发育所必需的，但 Reelin 的功能仍然存在争议。在这份报告中，我们利用大脑皮层的“层特异性标记”，对 Reelin 缺陷小鼠 Reeler 大脑中神经元亚群的空间分布进行了详细观察。我们观察到标记物在卷取器大脑皮层中的空间分散表达。这些标记物也在大脑的其他层状和非层状结构中表达，我们在这些结构中观察到类似的异常基因表达。我们的观察表明，大脑结构内的神经元（例如神经层和细胞核）通常表现出标记表达的集中分布，但由于缺乏 Reelin，它们的分离会松散或分散。
Neurons with similar functions including neuronal connectivity and gene expression form discrete condensed structures within the vertebrate brain. This is exemplified within the circuitry formed by the cortical layers and the neuronal nuclei. It is well known that the Reelin protein is required for development of these neuronal structures in rodents and human, but the function of Reelin remains controversial. In this report, we used "layer-specific markers" of the cerebral cortex to carry out detailed observations of spatial distribution of the neuronal subpopulations in the brain of the Reelin deficient mouse, reeler. We observed a spatially dispersed expression of the markers in the reeler cerebral cortex. These markers are expressed also in other laminated and non-laminated structures of brain, in which we observed similar abnormal gene expression. Our observations suggest that neurons within the brain structures (such as the layers and the nuclei), which normally exhibit condensed distribution of marker expressions, loosen their segregation or scatter by a lack of Reelin.