Diffusion tensor imaging for long-term follow-up of corticospinal tract degeneration in amyotrophic lateral sclerosis
Diffusion tensor imaging for long-term follow-up of corticospinal tract degeneration in amyotrophic lateral sclerosis
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DOI：
10.1007/s00234-003-1014-0
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发表时间：
2003-09-01
期刊：
影响因子：
2.8
通讯作者：
Ehrenreich, H
中科院分区：
文献类型：
--
作者：
Jacob, S;Finsterbusch, J;Ehrenreich, H
肌萎缩侧索硬化症（ALS）是一种主要的临床和肌电图诊断。常规MRI显示晚期运动系统萎缩，尤其是锥体束，但不能提供疾病进展的敏感指标。三名患者具有不同的ALS主要症状，即，分别主要累及上（UMN）或下（UMN）运动神经元或延髓疾病的患者进行了一系列临床检查，包括肺功能检查、常规MRI和扩散张量成像（DTI）。MRI显示锥体束的变化，随访时无可测量的变化。UMN受累的患者表现为锥体束弥散各向异性明显进行性丢失。DTI与临床随访一起，可作为治疗试验中的客观形态学标志物。
Amyotrophic lateral sclerosis (ALS) is a predominantly clinical and electromyographic diagnosis. Conventional MRI reveals atrophy of the motor system, particularly the pyramidal tract, in the advanced stages but does not provide a sensitive measure of disease progression. Three patients with different principal symptoms of ALS, i.e., with predominant involvement of the upper (UMN) or lower (UMN) motor neurons, or bulbar disease, respectively, underwent serial clinical examination including lung function tests, conventional MRI, and diffusion tensor imaging (DTI). MRI demonstrated changes in of the pyramidal tract without measurable variation on follow-up. The patient with UMN involvement showed remarkable progressive loss of diffusion anisotropy in the pyramidal tract. DTI might be useful, together with clinical follow-up, as an objective morphological marker in therapeutic trials.