New horizon for high performance Mg-based biomaterial with uniform degradation behavior: Formation of stacking faults.
New horizon for high performance Mg-based biomaterial with uniform degradation behavior: Formation of stacking faults.
复制标题
具有均匀降解行为的高性能镁基生物材料的新视野：堆垛层错的形成
DOI：
10.1038/srep13933
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发表时间：
2015-09-09
影响因子：
4.6
通讯作者：
Wu R
中科院分区：
文献类型：
--
作者：
Zhang J;Xu C;Jing Y;Lv S;Liu S;Fang D;Zhuang J;Zhang M;Wu R
设计新的微观结构是加速镁合金生物医学应用的有效途径。采用直冷半连续铸造、热处理和热挤压相结合的工艺制备了具有大量纳米间距基面层错的Mg-8Er-1Zn合金。SFs的形成使得该合金作为生物可降解植入材料具有优异的综合性能。含SFs的合金的极限抗拉强度（UTS: 318 MPa）、抗拉屈服强度（TYS: 207 MPa）和伸长率（21%）均优于已有报道的可降解mg基合金。该合金具有良好的生物毒性和降解速率（0.34 mm/年），并且可以通过优化微观结构进一步降低降解速率。最令人惊奇的是，由于SFs的形成，获得了独特的均匀的体外/体内腐蚀行为。在此基础上，提出了一种新颖的含SFs镁合金腐蚀机理。本研究为开发性能优良的新型镁基生物材料开辟了新的前景。
Designing the new microstructure is an effective way to accelerate the biomedical application of magnesium (Mg) alloys. In this study, a novel Mg–8Er–1Zn alloy with profuse nano-spaced basal plane stacking faults (SFs) was prepared by combined processes of direct-chill semi-continuous casting, heat-treatment and hot-extrusion. The formation of SFs made the alloy possess outstanding comprehensive performance as the biodegradable implant material. The ultimate tensile strength (UTS: 318 MPa), tensile yield strength (TYS: 207 MPa) and elongation (21%) of the alloy with SFs were superior to those of most reported degradable Mg-based alloys. This new alloy showed acceptable biotoxicity and degradation rate (0.34 mm/year), and the latter could be further slowed down through optimizing the microstructure. Most amazing of all, the uniquely uniform in vitro/vivo corrosion behavior was obtained due to the formation of SFs. Accordingly we proposed an original corrosion mechanism for the novel Mg alloy with SFs. The present study opens a new horizon for developing new Mg-based biomaterials with highly desirable performances.