CONTEXT, CORTEX, AND DOPAMINE - A CONNECTIONIST APPROACH TO BEHAVIOR AND BIOLOGY IN SCHIZOPHRENIA
CONTEXT, CORTEX, AND DOPAMINE - A CONNECTIONIST APPROACH TO BEHAVIOR AND BIOLOGY IN SCHIZOPHRENIA
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DOI：
10.1037/0033-295x.99.1.45
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发表时间：
1992-01-01
影响因子：
5.4
通讯作者：
SERVANSCHREIBER, D
中科院分区：
文献类型：
--
作者：
COHEN, JD;SERVANSCHREIBER, D
连接主义模型用于探索精神分裂症认知缺陷与生物学异常之间的关系。审查了涉及前额叶皮层和中皮层多巴胺系统的生物学障碍，审查了精神分裂症和语言处理的任务中的精神分裂缺陷。然后介绍了三个计算机模型，以模拟Stroop任务中的正常和精神分裂症性能，连续性能测试和词汇歧义任务。他们表明，在上下文信息的内部表示中的干扰可以为几个与注意力和语言有关的任务中的精神分裂症缺陷提供共同的解释。这些模型还表明，这些行为缺陷可能是由于模型参数（增益）的干扰引起的，该模型参数（增益）与多巴胺的神经调节作用相对应，在与前额叶皮质功能相对应的模型成分中。
Connectionist models are used to explore the relationship between cognitive deficits and biological abnormalities in schizophrenia. Schizophrenic deficits in tasks that tap attention and language processing are reviewed, as are biological disturbances involving prefrontal cortex and the mesocortical dopamine system. Three computer models are then presented that simulate normal and schizophrenic performance in the Stroop task, the continuous performance test, and a lexical disambiguation task. They demonstrate that a disturbance in the internal representation of contextual information can provide a common explanation for schizophrenic deficits in several attention- and language-related tasks. The models also show that these behavioral deficits may arise from a disturbance in a model parameter (gain) corresponding to the neuromodulatory effects of dopamine, in a model component corresponding to the function of prefrontal cortex.