Enhanced tumor therapy via drug co‐delivery and in situ vascular‐promoting strategy
Enhanced tumor therapy via drug co‐delivery and in situ vascular‐promoting strategy
复制标题
DOI：
10.1016/j.jconrel.2017.05.016
复制
发表时间：
2017-07
影响因子：
10.8
通讯作者：
M. Yin;Songwei Tan;Yuling Bao;Zhiping Zhang
中科院分区：
文献类型：
--
作者：
M. Yin;Songwei Tan;Yuling Bao;Zhiping Zhang
通过降低血管密度的传统肿瘤饥饿疗法可能在早期治疗中有效，但可能会导致肿瘤缺氧、耐药性和转移。一种通过增强肿瘤血管生成并结合有效化疗药物的新策略，已显示出成功的肿瘤生长和扩散抑制作用。为了实现肿瘤中血管生成和抗肿瘤药物的原位释放，我们设计了一种精确比例的聚合物混合胶束系统，用于共同递送一氧化氮和紫杉醇。杂化胶束可通过长血液循环和增强通透性和滞留（EPR）效应在肿瘤内积累，通过原位增加血管通透性、血液灌注和血管密度促进药物在肿瘤内的积累和渗透，通过改变肿瘤微环境实现一氧化氮和紫杉醇的协同抗肿瘤作用，克服多药耐药性并抑制转移。这项研究提出了一种针对肿瘤进展和扩散的联合疗法，显示出未来癌症治疗的巨大潜力。
Conventional tumor starving therapy by reducing its vessel density may be effective at early treatment but potentially contributes to tumor hypoxia, drug resistance and metastasis. A new strategy through enhancing tumor angiogenesis in combination with effective chemotherapeutic drugs, has shown successful tumor growth and spread inhibition. To achievein siturelease of angiogenic and antitumor drugs in tumor, we designed a precise ratiometric polymeric hybrid micelle system for co-delivering nitric oxide and paclitaxel. The hybrid micelles could accumulate in tumorviathe long blood circulation and enhanced permeability and retention (EPR) effect, promote the drug accumulation and penetration in tumor byin situincreased vascular permeability, blood perfusion and vessel density, achieve the synergistic antitumor effect of nitric oxide and paclitaxel through modified tumor microenvironment, overcome multidrug resistance and inhibit metastasis. This study presents a combinational therapy against tumor progression and spread, which shows great potential in cancer therapy of the future.