Characterization of human brown adipose tissue by chemical-shift water-fat MRI.
Characterization of human brown adipose tissue by chemical-shift water-fat MRI.
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DOI：
10.2214/ajr.12.8996
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Gilsanz V
中科院分区：
文献类型：
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作者：
Hu HH;Perkins TG;Chia JM;Gilsanz V
本研究的目的是用化学位移水脂肪磁共振成像来表征人类棕色脂肪组织(BAT)，并确定在婴儿、青少年和成人中，BAT和白色脂肪组织(WAT)在死后和活体中的脂肪信号部分和T2*弛豫时间的趋势和差异是否一致。对一具身体和8名病人进行了研究。扫描温度为3T时，采用六回波破坏的梯度回波化学位移水脂肪磁共振成像序列，联合测量肩峰间-锁骨上动脉和皮下动脉的脂肪信号分数和T2*。为了确认BAT的身份，在尸检中以活检和组织学为参考，在需要进行医疗检查的8名患者中，有5名使用了PET/CT。在尸检和8名患者中的7名患者中，BAT的脂肪信号分数和T2*时间低于WAT。除一例外，棕色和白色脂肪组织之间的名义比较具有统计学意义(p<；0.05)。在受试者之间，在BAT中观察到了很大范围的脂肪信号分数值，而在WAT中没有观察到。我们已经证明，由于细胞结构、甘油三酯含量和血管形成的差异，BAT患者的脂肪信号部分和T2*值联合来自化学位移水脂肪MRI的值低于WAT患者。这两项指标可作为BAT检测的互补生物标志物。
The purpose of this study was to characterize human brown adipose tissue (BAT) with chemical-shift water-fat MRI and to determine whether trends and differences in fat-signal fractions and T2* relaxation times between BAT and white adipose tissue (WAT) are consistently observed postmortem and in vivo in infants, adolescents, and adults. A postmortem body and eight patients were studied. A six-echo spoiled gradient-echo chemical-shift water-fat MRI sequence was performed at 3 T to jointly quantify fat-signal fraction and T2* in interscapular-supraclavicular BAT and subcutaneous WAT. To confirm BAT identity, biopsy and histology served as the reference in the postmortem study and PET/CT was used in five of the eight patients who required examination for medical care. Fat-signal fractions and T2* times were lower in BAT than in WAT in the postmortem example and in seven of eight patients. With the exception of one case, nominal comparisons between brown and white adipose tissues were statistically significant (p < 0.05). Between subjects, a large range of fat-signal fraction values was observed in BAT but not in WAT. We have shown that fat-signal fractions and T2* values jointly derived from chemical-shift water-fat MRI are lower in BAT than in WAT likely because of differences in cellular structures, triglyceride content, and vascularization. The two metrics can serve as complementary biomarkers in the detection of BAT.