The effect of low dose sevoflurane on saccadic eye movement latency
The effect of low dose sevoflurane on saccadic eye movement latency
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DOI：
10.1046/j.1365-2044.2002.02780.x
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发表时间：
2002-09-01
期刊：
影响因子：
10.7
通讯作者：
Jones, JG
中科院分区：
文献类型：
--
作者：
Carpenter, RHS;Descamps, MJL;Jones, JG
我们研究了低浓度七氟醚对跳眼运动任务的影响，该任务反映了高级神经决策和控制机制的表现。实验在五名受试者中进行双盲，使用含0.15%末潮七氟醚的氧气，或纯氧作为安慰剂。用计算机为基础的记录系统记录和分析眼跳，该系统也控制视觉目标的呈现。与呼吸空气相比，给氧对中位潜伏期无显著影响；但在五名受试者中的四名中，在氧气中施用七氟醚导致潜伏期显著增加。这些结果表明，测量正中跳眼潜伏期可能是麻醉恢复过程中功能损伤的有用功能测量。
We investigated the effects of a low concentration of sevoflurane on a saccadic eye movement task that reflects the performance of higher neural decision and control mechanisms. The experiments were performed double-blind in five subjects, using either 0.15% end-tidal sevoflurane in oxygen, or pure oxygen as a placebo. Saccades were recorded and analysed using a computer-based recording system that also controlled the presentation of visual targets. Administration of oxygen produced no significant change in median latency compared with breathing air; but in four of the five subjects, administration of sevoflurane in oxygen caused a significant increase in latency. These results suggest that measurement of median saccadic latency may be a useful functional measurement of impairment of performance during recovery from anaesthesia.