IMMUNE INTERFERON IN THE CIRCULATION OF PATIENTS WITH AUTO-IMMUNE DISEASE
IMMUNE INTERFERON IN THE CIRCULATION OF PATIENTS WITH AUTO-IMMUNE DISEASE
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DOI：
10.1056/nejm197907053010102
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发表时间：
1979-01-01
影响因子：
158.5
通讯作者：
NOTKINS, AL
中科院分区：
文献类型：
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作者：
HOOKS, JJ;MOUTSOPOULOS, HM;NOTKINS, AL
II型或免疫干扰素可以在体外免疫特异性基础上由外周血白细胞产生，这表明它也可能在体内各种自身免疫性疾病中产生。我们在系统性红斑狼疮、类风湿关节炎、硬皮病和Sjögren综合征患者的血清中发现免疫干扰素。在28例系统性红斑狼疮患者中，71%的活动性红斑狼疮患者血清中有干扰素，21%的非活动性红斑狼疮患者血清中有干扰素。系列血清样本显示干扰素滴度与疾病活动性之间有良好的相关性。此外，干扰素滴度与DNA抗体呈正相关，与血清补体第三组分水平呈负相关。干扰素的产生可能有助于自身免疫性疾病的免疫异常，也可能保护已经受损的宿主免受病毒感染。（中华医学杂志31:5 - 8,1979）
The observation that type II, or immune, interferon could be produced by peripheral-blood leukocytes in vitro on an immune-specific basis suggested that it also might be produced in vivo in various autoimmune disorders. We found immune interferon in the serums of patients with systemic lupus erythematosus, rheumatoid arthritis, scleroderma and Sjögren's syndrome. Among 28 patients with systemic lupus erythematosus, 71 per cent of those with active and 21 per cent of those with inactive disease showed interferon in their serums. Serial serum samples showed a good correlation between interferon titers and disease activity. Moreover, interferon titers correlated positively with antibodies to DNA and negatively with serum levels of the third component of complement. It is possible that the production of interferon may contribute to immunologic aberrations in autoimmune diseases and also protect the already compromised host from viral infections. (N Engl J Med 301:5–8, 1979)