Primary, systemic amyloidosis and the dermatologist: where classic skin lesions may provide the clue for early diagnosis.
Primary, systemic amyloidosis and the dermatologist: where classic skin lesions may provide the clue for early diagnosis.
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原发性系统性淀粉样变性和皮肤科医生：典型的皮肤病变可能为早期诊断提供线索。
DOI：
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发表时间：
2005
影响因子：
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通讯作者：
S. R. Silverstein
中科院分区：
文献类型：
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作者：
S. R. Silverstein
原发性淀粉样变性可表现为皮肤损害，作为基础浆细胞恶液质的原发或唯一表现。列出了原发性、系统性淀粉样变性的典型皮肤病变，并讨论了提示诊断的特征。如果这种情况被认为是在皮肤科医生的区别，调查所描述的可能导致早期诊断。当治疗可以在器官衰竭发作之前开始时，生存期可能会延长。
Primary amyloidosis may present with skin lesions as a primary or sole expression of underlying plasma-cell dyscrasia. Classic skin lesions of primary, systemic amyloidosis are listed, and features suggestive of the diagnosis are discussed. Where this condition is considered in the dermatologist's differential, the investigations described may lead to an early diagnosis. When therapy can be initiated before the onset of organ failure, survival may be prolonged.