Patient preferences for next generation neural prostheses to restore bladder function
Patient preferences for next generation neural prostheses to restore bladder function
复制标题
DOI：
10.1038/sc.2010.65
复制
发表时间：
2011-01-01
期刊：
影响因子：
2.2
通讯作者：
Gustafson, K. J.
中科院分区：
文献类型：
--
作者：
Sanders, P. M. H.;IJzerman, M. J.;Gustafson, K. J.
研究设计：对66名脊髓损伤（SCI）患者进行基于选择的联合（CBC）分析。定义了六个属性，每个属性有三个水平，并用于生成治疗方案的选择集。患者被要求选择的情况下，他们prefermentmost. Objective. To确定的效用权重的治疗特点，以及整体偏好的三种类型的神经假体（NP），即Brindley，神经根切断术免费Brindley，和阴部神经刺激。早期研究已经揭示了恢复膀胱功能的重要性，但尚未进行任何研究来确定NP特征的重要性。设置：两个学术附属医疗系统的SCI门诊和住院康复项目，俄亥俄州克利夫兰。方法：CBC分析，然后是多项logit建模。结果：副作用对受试者选择的影响最大，其次是对排尿和排尿的有效性。与阴部传入神经刺激（39%的第二选择）和骶神经根刺激伴神经根切断术（53%的第三选择）相比，首选无神经根切断术骶神经根刺激的NP（45%的首选）。几乎20%的人不想在任何时候都有一个NP。结论：CBC已被证明是一个有价值的工具，以支持设计选择。数据显示，人们更喜欢带有微创电极的膀胱NP，这将为他们提供完整的膀胱功能，没有副作用，并且可以通过按下按钮进行操作，并且他们不必自己充电。Spinal Cord（2011）49，113-119; doi：10.1038/sc.2010.65; 2010年6月8日在线发表
Study design: A survey administered to 66 individuals with spinal cord injury (SCI) implementing a choice-based conjoint (CBC) analysis. Six attributes with three levels each were defined and used to generate choice sets with treatment scenarios. Patients were asked to choose the scenario that they preferred most.Objectives: To determine the utility weights for treatment characteristics as well as the overall preference for the three types of neural prostheses (NP), that is Brindley, rhizotomy-free Brindley, and pudendal nerve stimulation. Earlier studies have revealed the importance of restoration of bladder function, but no studies have been performed to determine the importance of NP features.Setting: Two academic affiliated medical systems' SCI outpatient and inpatient rehabilitation programs, Cleveland, OH.Methods: CBC analysis followed by multinomial logit modeling. Individual part-worth utilities were estimated using hierarchical Bayes.Results: Side effects had the greatest significant impact on subject choices, followed by the effectiveness on continence and voiding. NPs with rhizotomy-free sacral root stimulation were preferred (45% first choice) over pudendal afferent nerve stimulation (39% second choice) and sacral root stimulation with rhizotomy (53% third choice). Almost 20% did not want to have an NP at all times.Conclusion: CBC has shown to be a valuable tool to support design choices. The data showed that persons would prefer a bladder NP with minimally invasive electrodes, which would give them complete bladder function, with no side effects and that can be operated by pushing a button and they do not have to recharge themselves. Spinal Cord (2011) 49, 113-119; doi: 10.1038/sc.2010.65; published online 8 June 2010