Apelin activates L-arginine/nitric oxide synthase/nitric oxide pathway in rat aortas.
Apelin activates L-arginine/nitric oxide synthase/nitric oxide pathway in rat aortas.
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Apelin 激活大鼠主动脉中的 L-精氨酸/一氧化氮合酶/一氧化氮途径。
DOI：
10.1016/j.peptides.2007.07.016
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发表时间：
2007-10-01
期刊：
影响因子：
3
通讯作者：
Qi, Yong Fen
中科院分区：
文献类型：
--
作者：
Jia, Yue Xia;Lu, Zheng Fei;Qi, Yong Fen
最近在离体大鼠心脏中发现Apelin是一种肌力多肽，静脉注射Apelin可引起短暂性血压下降。为了阐明apelin诱导血管舒张的机制，我们在体外观察了apelin对培养、离体大鼠主动脉中l -精氨酸(L-Arg)/一氧化氮（NO）通路的影响。Apelin以浓度和时间依赖的方式刺激血管NO(2)（-）产物和NOS激活。与不加apelin处理相比，用apelin(10（-9）、10（-8）和10(-7)mol/L孵育使no(2)（-）生成量分别增加33%、46%和69%(均p
Apelin was recently found to be an inotropic polypeptide in isolated rat hearts, and intravenous injection of apelin can induce a transient decrease in blood pressure. To illustrate the mechanism of apelin-induced vasodilation, we observed the in vitro effects of apelin on the L-arginine (L-Arg)/nitric oxide (NO) pathway in the incubated, isolated rat aorta. Apelin stimulated vascular NO(2)(-) product and NOS activation in a concentration- and time-dependent manner. Compared with no apelin treatment, incubation with apelin (10(-9), 10(-8), and 10(-7)mol/L) increased NO(2)(-) product by 33%, 46%, and 69% (all p