The diversity of Rab proteins in vesicle transport
The diversity of Rab proteins in vesicle transport
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DOI：
10.1016/s0955-0674(97)80025-7
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发表时间：
1997-08-01
影响因子：
7.5
通讯作者：
Zerial, M
中科院分区：
文献类型：
--
作者：
Novick, P;Zerial, M
RAB蛋白主要参与囊泡停靠，作为圈套配对的调节因子。然而，最近的发现表明，它们在囊泡运输中的功能可以超越这一角色，一些彼此无关的蛋白质已被确定为假定的Rab效应器。虽然Rab蛋白的GTPase开关是高度保守的，但在Rab家族的成员中，功能机制可能是高度多样化的。
Rab proteins have been primarily implicated in vesicle docking as regulators of SNARE pairing. Recent findings, however, indicate that their function in vesicle trafficking can go beyond this role, and a number of proteins, unrelated to each other, have been identified as putative Rab effectors. Although the GTPase switch of Rab proteins is highly conserved, functional mechanisms may be highly diversified among members of the Rab family.