Presence of Intratumoral Neutrophils Is an Independent Prognostic Factor in Localized Renal Cell Carcinoma
Presence of Intratumoral Neutrophils Is an Independent Prognostic Factor in Localized Renal Cell Carcinoma
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DOI：
10.1200/jco.2008.18.9498
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发表时间：
2009-10-01
影响因子：
45.3
通讯作者：
von der Maase, Hans
中科院分区：
文献类型：
--
作者：
Jensen, Hanne Krogh;Donskov, Frede;von der Maase, Hans
目的
我们先前已证明肿瘤内中性粒细胞在转移性肾细胞癌中具有显著的负面影响。本研究评估了局限性透明细胞肾细胞癌（RCC）中的肿瘤内中性粒细胞。
患者与方法
该研究纳入了121例因局限性RCC接受肾切除术的连续患者。通过免疫组织化学评估生物标志物（肿瘤内CD8 +、CD57 +免疫细胞、CD66b +中性粒细胞和碳酸酐酶IX [CA IX]），并评估其与临床和组织病理学特征以及患者预后的关系。
结果
肿瘤内中性粒细胞在每平方毫米肿瘤组织中数量从0到289个不等。肿瘤内中性粒细胞的存在与肿瘤增大、血红蛋白降低、肌酐升高以及CA IX在统计学上显著相关。
PurposeWe have previously demonstrated a significant negative impact of intratumoral neutrophils in metastatic renal cell carcinoma. This study assessed intratumoral neutrophils in localized clear cell renal cell carcinoma (RCC).Patients and MethodsThe study comprised 121 consecutive patients who had a nephrectomy for localized RCC. Biomarkers (intratumoral CD8+, CD57+ immune cells, CD66b+ neutrophils, and carbonic anhydrase IX [CA IX]) were assessed by immunohistochemistry, and the relationship with clinical and histopathologic features and patient outcome was evaluated.ResultsThe intratumoral neutrophils ranged from zero to 289 cells/mm(2) tumor tissue. The presence of intratumoral neutrophils was statistically significantly associated with increasing tumor size, low hemoglobin, high creatinine, and CA IX