Simultaneous self-assembly, orientation, and patterning of peptide-amphiphile nanofibers by soft lithography
Simultaneous self-assembly, orientation, and patterning of peptide-amphiphile nanofibers by soft lithography
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DOI：
10.1021/nl062835z
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发表时间：
2007-05-01
期刊：
影响因子：
10.8
通讯作者：
Stupp, Samuel I.
中科院分区：
文献类型：
--
作者：
Hung, Albert M.;Stupp, Samuel I.
肽-两亲分子自组装纳米纤维由于其在体内外的生物活性而引起人们极大的兴趣。在这项工作中，我们展示了同时自组装，对齐，和图案化的这些纳米纤维在大面积的一种新的技术，称为超声辅助的解决方案压花。在这种软光刻技术中，纳米结构通过溶剂蒸发自组装，同时在超声波搅拌和限制在弹性体印模的形貌特征内的影响下。当纳米纤维从溶液中组装出来时，它们平行于通道取向，在移除印模后在基底上产生对齐的纳米纤维束。排列可能是空间限制的结果，并且可能是溶剂蒸发时向溶致液晶相的转变。这种技术并不限于单轴对齐，并被证明能够引导纳米纤维绕圈。通过这种方法排列纳米结构引入了通过调节纳米尺度上相互作用的方向性来控制宏观尺度细胞行为或材料性质的可能性。
Self-assembled nanofibers of peptide-amphiphile molecules have been of great interest because of their bioactivity both in vitro and in vivo. In this work, we demonstrate the simultaneous self-assembly, alignment, and patterning of these nanofibers over large areas by a novel technique termed sonication-assisted solution embossing. In this soft lithographic technique, the nanostructures self-assemble by solvent evaporation while under the influence of ultrasonic agitation and confinement within the topographical features of an elastomeric stamp. The nanofibers orient parallel to the channels as they assemble out of solution, yielding bundles of aligned nanofibers on the substrate after the stamp is removed. Alignment is likely a result of steric confinement and possibly a transition to a lyotropic liquid crystalline phase as solvent evaporates. This technique is not limited to uniaxial alignment and is shown to be able to guide nanofibers around turns. Alignment of nanostructures by this method introduces the possibility of controlling macroscale cellular behavior or material properties by tuning the directionality of interactions at the nanoscale.