QUANTITATIVE MAGNETIC-RESONANCE-IMAGING PARAMETERS AND THEIR RELATIONSHIP TO MAMMOGRAPHIC PATTERN
QUANTITATIVE MAGNETIC-RESONANCE-IMAGING PARAMETERS AND THEIR RELATIONSHIP TO MAMMOGRAPHIC PATTERN
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DOI：
10.1093/jnci/84.10.777
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发表时间：
1992-05-20
期刊：
影响因子：
--
通讯作者：
BOYD, NF
中科院分区：
文献类型：
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作者：
POON, CS;BRONSKILL, MJ;BOYD, NF
背景资料：乳腺癌的发病率在国际上有很大的差异，这导致了与疾病风险相关的几个因素的确定。磁共振成像（MRI）技术可以提供关于组织的生物和物理性质的定量信息。目的：这项工作测试了几种磁共振组织参数，以确定它们在乳腺癌风险显著不同的受试者中定量区分乳腺组织的能力，这些乳腺癌风险由乳腺X线片上的实质模式间接定义。研究方法：使用新开发的技术，在两组乳腺摄影实质外观与高Dy模式相关的女性中测量乳腺组织的定量MRI参数（相对含水量、纵向弛豫时间[T1]和横向弛豫时间[T2]）[即，广泛结节状或弥漫性密度]; n = 12）或低密度（N1型[即，乳腺主要含有脂肪]; n = 11）乳腺癌的风险。结果：两组的平均相对含水量（P < .0001）和平均T1（P < .0001）有显著差异。T2值的像素直方图显示两组之间的显著差异，其可以用四阶矩参数表征。结论：定量MRI技术在评估与乳腺癌风险相关的乳腺组织特征方面表现出良好的潜力。意义：未来的工作将解决MRI参数与乳腺癌风险的直接相关性。
Background: Breast cancer exhibits wide international variation in incidence, which has led to the identification of several factors correlating with the risk of the disease. Magnetic resonance imaging (MRI) techniques can provide quantitative information about the biological and physical properties of tissue. Purpose: This work tested several magnetic resonance tissue parameters for their ability to distinguish quantitatively between breast tissues in subjects at substantially different risk for breast cancer as defined indirectly by their parenchymal pattern on mammograms. Methods: Quantitative MRI parameters (relative water content, longitudinal relaxation time [T1], and transverse relaxation time [T2]) were measured for breast tissue using newly developed techniques in two groups of women with mammographic parenchymal appearance associated with high (Dy pattern [i.e., extensive nodular or diffuse density]; n = 12) or low (N1 pattern [i.e., breast containing mainly fat]; n = 11) risk of breast cancer. Results: The two groups have significantly different average relative water content (P < .0001) and average T1 (P < .0001). Pixel histograms of T2 values show marked differences between the two groups which can be characterized with a fourth moment parameter. Conclusions: Quantitative MRI techniques exhibit good potential for assessing tissue characteristics in the breast that are associated with risk of breast cancer. Implications: Future work will address the direct correlation of MRI parameters with risk of breast cancer.