Delusions of alien control in the normal brain
Delusions of alien control in the normal brain
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DOI：
10.1016/s0028-3932(02)00313-5
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发表时间：
2003-01-01
期刊：
影响因子：
2.6
通讯作者：
Frith, CD
中科院分区：
文献类型：
--
作者：
Blakemore, SJ;Oakley, DA;Frith, CD
外来控制妄想或被动体验是与精神分裂症相关的症状，其中患者将自我产生的行为错误地归因于外部来源。在这项研究中，催眠被用来在正常、健康的个体中诱导类似的自我产生运动的错误归因。正电子发射断层扫描 (PET) 用于研究正确归因于自身的主动运动的神经相关性，与错误归因于外部源的相同主动运动进行比较。归因于外部来源的主动运动导致顶叶皮层和小脑的激活明显高于正确归因于自身的相同主动运动。我们认为，催眠暗示的结果是，小脑-顶叶网络的功能发生了改变，从而使自我产生的行为被体验为外部行为。这些结果对控制妄想背后的大脑机制有影响，这可能与小脑-顶叶网络的过度激活有关。 (C) 2003 Elsevier Science Ltd. 保留所有权利。
Delusions of alien control, or passivity experiences, are symptoms associated with schizophrenia in which patients misattribute self-generated actions to an external source. In this study hypnosis was used to induce a similar misattribution of self-generated movement in normal, healthy individuals. Positron Emission Tomography (PET) was employed to investigate the neural correlates of active movements correctly attributed to the self, compared with identical active movements misattributed to an external source. Active movements attributed to an external source resulted in significantly higher activations in the parietal cortex and cerebellum than identical active movements correctly attributed to the self. We suggest that, as a result of hypnotic suggestion, the functioning of this cerebellar-parietal network is altered so that self-produced actions are experienced as being external. These results have implications for the brain mechanisms underlying delusions of control, which may be associated with overactivation of the cerebellar-parietal network. (C) 2003 Elsevier Science Ltd. All rights reserved.