PROPYLTHIOURACIL TASTING - DETERMINATION OF UNDERLYING THRESHOLD DISTRIBUTIONS USING MAXIMUM-LIKELIHOOD
PROPYLTHIOURACIL TASTING - DETERMINATION OF UNDERLYING THRESHOLD DISTRIBUTIONS USING MAXIMUM-LIKELIHOOD
复制标题
DOI：
10.1093/chemse/20.5.529
复制
发表时间：
1995-10-01
期刊：
影响因子：
3.5
通讯作者：
PRICE, RA
中科院分区：
文献类型：
--
作者：
REED, DR;BARTOSHUK, LM;PRICE, RA
尝出低浓度丙基硫氧嘧啶（PROP）和相关苦味化合物的能力是可遗传的。目前的分析确定PROP味觉阈值的分布是否与孟德尔传播的加性或显性模式一致。为此，确定了1015名受试者的PROP可检测的最低浓度，并测试了PROP味觉阈值的双峰或三峰分布模型。具有最大可能性的模型具有三个分布，并且如果假设与分布相关的方差相等，则遵循PROP味觉敏感性的加性模型。然而，如果味觉阈值被转换以去除偏度，或者如果方差不相等，则三分布或二分布模型同样可能。苦味感知的遗传模式的决议等待额外的家庭研究和表征这些苦味化合物的味觉的分子基础。
The ability to taste low concentrations of propylthiouracil (PROP) and related bitter compounds is heritable. The current analysis determines whether the distribution of PROP taste thresholds is consistent with an additive or a dominant mode of Mendelian transmission. To that end, the lowest concentration of PROP detectable was determined for 1015 subjects and models of bi- or tri-modal distributions of PROP taste thresholds were tested. The model with the greatest likelihood had three distributions and followed an additive model of PROP taste sensitivity if the variances associated with the distributions were assumed to be equal. However, if the taste thresholds were transformed to remove skewness, or if the variances were unequal, then three- or two-distribution models were equally likely. Resolution of the mode of inheritance for bitter taste perception awaits additional family studies and the characterization of the molecular basis of taste perception for these bitter compounds.