Embryonal rhabdomyosarcoma of the uterine cervix
Embryonal rhabdomyosarcoma of the uterine cervix
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DOI：
10.1007/s12094-009-0376-0
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发表时间：
2009-06-01
影响因子：
3.4
通讯作者：
Gouliamos, Athanasios
中科院分区：
文献类型：
--
作者：
Koukourakis, Georgios V.;Kouloulias, Vassilios;Gouliamos, Athanasios
子宫颈胚胎性横纹肌肉瘤是一种罕见且恶性程度极高的肿瘤。一般来说，起源于子宫颈的胚胎性RMS通常在青春期被诊断。在引入有效的辅助化疗之前，这些病变的预后很差。我们已经治疗了一名患有这种疾病的年轻女子，使用手术，化疗和放射治疗（RT）的组合，效果非常好。子宫颈胚胎性横纹肌肉瘤虽然罕见且恶性，但只要适当治疗，是可以治愈的。组织学检查显示子宫颈的胚胎性横纹肌肉瘤。该患者的治疗与手术，化疗和RT的组合。在文献中的审查，这也是提出，表明胚胎RMS使用手术和多药化疗的联合治疗有显着改善survival.Patients预后良好的参数，如局部疾病没有深肌层浸润，单一息肉和胚胎组织学亚型，可以有效地通过手术治疗。预后参数不利的患者似乎受益于多模式方法，包括手术，辅助化疗和RT。
Embryonal rhabdomyosarcoma (RMS) of the uterine cervix is a rare and extremely malignant entity. Generally, embryonal RMS originating in the uterine cervix is usually diagnosed in adolescence. Before the introduction of effective adjuvant chemotherapy, the prognosis of these lesions was poor. We have treated a young woman suffering from this disease using a combination of surgery, chemotherapy and radiation therapy (RT) with excellent results. The medical community should keep in mind that embryonal RMS of the uterine cervix, despite its malignancy and rarity, can be cured if adequate treatment is given.A case of a young woman aged 20, presenting with vaginal bleeding, is reported. The histological examination revealed embryonal RMS of uterine cervix. The patient was treated with a combination of surgery, chemotherapy and RT. A review in the literature, which is also presented, shows that the combined treatment of embryonal RMS using surgery and multidrug chemotherapy has significantly improved survival.Patients with favourable prognostic parameters, such as localised disease without deep myometrial invasion, single polyp and embryonal histologic subtype, can effectively be treated by surgery. Patients with unfavourable prognostic parameters seem to benefit from a multimodality approach including surgery, adjuvant chemotherapy and RT.