Global analysis of differentially expressed genes in androgen-independent prostate cancer
Global analysis of differentially expressed genes in androgen-independent prostate cancer
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DOI：
10.1038/sj.pcan.4500933
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发表时间：
2007-05-01
影响因子：
4.8
通讯作者：
Li, Y.
中科院分区：
文献类型：
--
作者：
Wei, Q.;Li, M.;Li, Y.
进展为雄激素非依赖性(AI)是前列腺癌死亡的主要原因，其机制尚不清楚。通过整体回顾26个前列腺癌样本的表达谱，我们发现了一组在AI中与雄激素依赖组相比差异表达的基因(P值<；0.01，t检验)。围绕细胞凋亡、增殖、激素和血管生成等方面的研究，我们发现在AI前列腺癌中上调的硫氧还蛋白结构域5、肿瘤坏死因子受体超家族成员10a、核糖体蛋白S19和Janus kinas2等基因可能在AD向AI转化过程中发挥重要作用，并可作为判断预后的生物标志物。
Progression to androgen independent ( AI) is the main cause of death in prostate cancer, and the mechanism is still unclear. By reviewing the expression profiles of 26 prostate cancer samples in a holistic view, we found a group of genes differentially expressed in AI compared with androgen-dependent groups ( P- value < 0.01, t- test). Focusing on apoptosis, proliferation, hormone and angiogenesis, we found a group of genes such as thioredoxin domain containing 5, tumor necrosis factor receptor superfamily, member 10a, ribosomal protein S19 and Janus kinase 2 upregulated in AI prostate cancer, could play important roles in the transition from AD to AI and could be biomarkers of prognosis.