Automated complete slide digitization: a medium for simultaneous viewing by multiple pathologists
Automated complete slide digitization: a medium for simultaneous viewing by multiple pathologists
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DOI：
10.1002/path.972
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发表时间：
2001-11-01
影响因子：
7.3
通讯作者：
McGee, J
中科院分区：
文献类型：
--
作者：
Leong, FJWM;McGee, J
远程病理学机器人系统的发展已经发展了处理“数字载玻片”的“虚拟显微镜”的概念。载玻片数字化是一种以数字（数字）形式存档显著组织学特征的方法。若干国际中心已开始认识到这一点的价值和潜力。自动化的完整载玻片数字化在临床实践的各个层面都有应用，并将使本科生、研究生和继续教育受益。不幸的是，由于组织学载玻片上的潜在数据量在数字化、存储和后续操作方面代表了一个重大问题，因此迄今为止虚拟显微镜的现实包括分辨率不足的有限视图。本文概述了在作者的实验室，它采用了增强的硬件，图像捕获和处理技术的组合，设计用于远程病理学的系统。该系统能够以高放大率扫描整个载玻片，并创建可能存在于互联网服务器上或分布在可移动介质（如CD-ROM或DVD）上的此类载玻片库。数字载玻片允许在传统光学显微镜不可能的水平上操作图像数据。多个用户的组合，多个放大，注释，以及添加辅助文本和视觉数据现在是可能的。这表明，随着复杂性的增加，远程病理学技术的应用不需要局限于第二意见，而是可以在更广泛的战线上扩展。版权所有（C）2001约翰威利父子有限公司
Developments in telepathology robotic systems have evolved the concept of a 'virtual microscope' handling 'digital slides'. Slide digitization is a method of archiving salient histological features in numerical (digital) form. The value and potential of this have begun to be recognized by several international centres. Automated complete slide digitization has application at all levels of clinical practice and will benefit undergraduate, postgraduate, and continuing education. Unfortunately, as the volume of potential data on a histological slide represents a significant problem in terms of digitization, storage, and subsequent manipulation, the reality of virtual microscopy to date has comprised limited views at inadequate resolution. This paper outlines a system refined in the authors' laboratory, which employs a combination of enhanced hardware, image capture, and processing techniques designed for telepathology. The system is able to scan an entire slide at high magnification and create a library of such slides that may exist on an internet server or be distributed on removable media (such as CD-ROM or DVD). A digital slide allows image data manipulation at a level not possible with conventional light microscopy. Combinations of multiple users, multiple magnifications, annotations, and addition of ancillary textual and visual data are now possible. This demonstrates that with increased sophistication, the applications of telepathology technology need not be confined to second opinion, but can be extended on a wider front. Copyright (C) 2001 John Wiley & Sons, Ltd.