Long-term exercise training decreases interleukin-6 (IL-6) Serum levels in subjects with impaired glucose tolerance:: effect of the-174G/C variant in IL-6 gene
Long-term exercise training decreases interleukin-6 (IL-6) Serum levels in subjects with impaired glucose tolerance:: effect of the-174G/C variant in IL-6 gene
复制标题
DOI：
10.1530/eje-08-0220
复制
发表时间：
2008-08-01
影响因子：
5.8
通讯作者：
Kovacs, Peter
中科院分区：
文献类型：
--
作者：
Oberbach, Andreas;Lehmann, Stefanie;Kovacs, Peter
目的：运动训练已被证明对2型糖尿病患者具有抗炎作用。训练后白细胞介素-6（ILA）血清浓度的变化可能有助于这些有益效果。然而.关于循环IL-6是否被运动训练改变，有不同的数据。因此，我们假设，遗传因素修改长期training.Research设计和方法后，IL-6水平的个体变化：IL-6基因的-174 G/C变异的基因型在60个受试者与糖耐量受损。在为期12个月的干预性研究中，患者被随机分为3组：对照组（n =16），一组接受标准化训练计划（n=24），另一组接受罗格列酮4 mg每日1次（n=20）。在基线，1，6和12个月后，我们确定了葡萄糖耐量和健身水平。11-6和。在基线和12个月后。结果：只有在携带SNP-174 C等位基因的受试者中，长期运动训练导致血清IL-6浓度显著降低。多元线性回归分析确定IL-6基因型作为独立于年龄的IL-6血清浓度变化的重要预测因子。性别和改善的身体质量指数，血红蛋白（I-Ib）A（1c），和健身水平在响应training.Conclusions：在IL-6基因的遗传变异显着修改IL-6血清浓度的变化，长期运动训练计划不良反应。我们的数据表明，遗传因素是个体对运动训练抗炎作用反应的重要决定因素。
Objective: Exercise training has been shown to have anti-inflammatory effects in patients with type 2 diabetes. Changes in interleukin-6 (ILA) serum concentrations in response to training could contribute to these beneficial effects. However. there are heterogeneous data on whether circulating IL-6 is altered by exercise training. We therefore hypothesize that genetic factors modify the individual changes in IL-6 levels after long-term training.Research design and methods: The -174G/C variant ill the IL-6 gene was genotyped in 60 Subjects with impaired glucose tolerance. For a 12-month interventional study, patients were randomized into three groups: it control group (n =16) was compared with one group, which underwent a standardized training program (n=24) and another group, which was treated with 4 mg rosiglitazone once daily (n=20). At baseline, after 1, 6,and 12 months, we determined glucose tolerance and fitness level. of 11-6 and. at baseline and after 12 months. we determined glucose tolerance and fitness level.Results: Only in subjects carrying the SNP -174C allele did long-term exercise training result in significantly reduced IL-6 serum concentrations. Multivariate linear regression analysis identified the IL-6 genotype as a significant predictor of changes in IL-6 serum concentrations independent of age. gender and improvement in body mass index, hemoglobin (I-Ib)A(1c), and fitness level in response to training.Conclusions: Genetic variants in the IL-6 gene significantly modify changes in IL-6 serum concentrations ill response to long-term exercise training programs. Our data Suggest that genetic factors are important determinants for the individual response to anti-inflammatory effects of exercise training.