A novel blood transfusant candidate: intact human erythrocytes containing hemoglobin exclusively nitrosylated in the alpha-subunits.
A novel blood transfusant candidate: intact human erythrocytes containing hemoglobin exclusively nitrosylated in the alpha-subunits.
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一种新型输血候选物：完整的人红细胞，其血红蛋白的α亚基完全被亚硝基化。
DOI：
10.1007/978-1-4615-0205-0_16
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发表时间：
2003
影响因子：
--
通讯作者：
Yonetani,Takashi
中科院分区：
文献类型：
--
作者：
Tsuneshige,Antonio;Yonetani,Takashi
氧气从肺部输送到周围组织是由血红蛋白 (Hb) 进行的，血红蛋白是红细胞内的主要蛋白质成分。然而，其生理性能的调节受到细胞内代谢物含量的调节，主要是2,3-二磷酸甘油酸（DPG），它将血红蛋白的氧亲和力降低到最佳水平，从而在肺和组织之间的窄氧分压梯度内完成有效的氧输送。然而，储存血液中DPG的细胞内水平随着时间的推移而衰减，导致氧亲和力逐渐增加，从而限制了血液的实际使用寿命。
The transport of oxygen from lungs to peripheral tissues is carried out by hemoglobin (Hb), the main protein component inside red blood cells. However, the modulation of its physiological performance is regulated by the intracellular content of metabolites, mainly 2,3-diphosphoglycerate (DPG), which lower the oxygen affinity of Hb to optimal levels, so that an efficient oxygen delivery is accomplished within a narrow gradient in partial pressures of oxygen between lungs and tissues. However, intracellular levels of DPG in stored blood decay with time, which causes a gradual increase in oxygen affinity, thus imposing a limit to the lifetime of blood for practical use.