Direction-selective adaptation in fly visual motion-sensitive neurons is generated by an intrinsic conductance-based mechanism
Direction-selective adaptation in fly visual motion-sensitive neurons is generated by an intrinsic conductance-based mechanism
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果蝇视觉运动敏感神经元的方向选择性适应是由基于内在电导的机制产生的
DOI：
10.1016/j.neuroscience.2007.01.058
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发表时间：
2007
期刊：
影响因子：
3.3
通讯作者：
R. Kurtz
中科院分区：
文献类型：
--
作者：
R. Kurtz
果蝇脑内运动敏感神经元是研究视觉运动适应的细胞机制和功能意义的理想模型系统。各种适应过程已经被描述过，但在很大程度上仍然不知道这些过程中哪些是在运动敏感神经元本身中产生的，哪些起源于更外围的处理阶段。通过测量输入电阻，我证明了方向选择性适应是由运动敏感神经元的活动依赖性电导增加产生的。基于树突状细胞Ca2+积累和兴奋性刺激后的慢超极化后电位之间的相关性，以前已经提出了由Ca2+调节方向选择性适应。然而，在本研究中，适应现象不诱发时，胞浆中的Ca2+浓度升高，而不是由运动刺激的单个神经元中的笼状Ca2+的紫外线光解。这一结果使得它不太可能，适应苍蝇运动敏感神经元调节散装胞质Ca 2+。
Motion-sensitive neurons in the blowfly brain present an ideal model system to study the cellular mechanisms and functional significance of adaptation to visual motion. Various adaptation processes have been described, but it is still largely unknown which of these processes are generated in the motion-sensitive neurons themselves and which originate at more peripheral processing stages. By input resistance measurements I demonstrate that direction-selective adaptation is generated by an activity-dependent conductance increase in the motion-sensitive neurons. Based on correlations between dendritic Ca2+accumulation and slow hyperpolarizing after-potentials following excitatory stimulation, a regulation of direction-selective adaptation by Ca2+has previously been suggested. In the present study, however, adaptation phenomena are not evoked when the cytosolic Ca2+concentration is elevated by ultraviolet photolysis of caged Ca2+in single neurons rather than by motion stimulation. This result renders it unlikely, that adaptation in fly motion-sensitive neurons is regulated by bulk cytosolic Ca2+.
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影响因子：
2.5
作者：
P. Schwindt;W. J. Spain;W. Crill
通讯作者：
P. Schwindt;W. J. Spain;W. Crill
DOI：
10.1073/pnas.84.10.3496
发表时间：
1987-05-01
影响因子：
11.1
作者：
GURNEY, AM;TSIEN, RY;LESTER, HA
通讯作者：
LESTER, HA
影响因子：
2.5
作者：
Anderson, JS;Carandini, M;Ferster, D
通讯作者：
Ferster, D
影响因子：
56.9
作者：
Carandini, M;Ferster, D
通讯作者：
Ferster, D