Education and APOE-e4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging.
Education and APOE-e4 in longitudinal cognitive decline: MacArthur Studies of Successful Aging.
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DOI：
10.1093/geronb/60.2.p74
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发表时间：
2005-03
期刊：
影响因子：
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通讯作者：
T. Seeman;Mei-hua Huang;P. Bretsky;E. Crimmins;L. Launer;J. Guralnik
中科院分区：
文献类型：
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作者：
T. Seeman;Mei-hua Huang;P. Bretsky;E. Crimmins;L. Launer;J. Guralnik
麦克阿瑟成功衰老研究的纵向数据用于测试教育和载脂蛋白E（APOE）基因型之间在认知表现时间趋势方面的相互作用。教育，APOE-e4状态和时间之间的相互作用被发现用于整体认知功能，以及用于测量记忆和命名的子量表：e4等位基因的存在与那些具有大于八年级教育的人的认知急剧下降相关。对于那些八年级或更低的教育，时间趋势没有不同的APOE基因型。认知障碍的量度（即，简易精神状态调查表得分<或= 7）产生了关于认知障碍风险的类似相互作用的平行但较弱的证据。这些发现表明，至少一个e4等位基因的存在似乎会降低那些至少有九年级或更高教育水平的人的教育保护作用，导致认知能力随着年龄的增长而急剧下降。
Longitudinal data from the MacArthur Study of Successful Aging were used to test for interactions between education and apolipoprotein E (APOE) genotype with respect to time trends in cognitive performance. Interactions between education, APOE-e4 status, and time were found for overall cognitive function, and for subscales measuring memory and naming: The presence of the e4 allele was associated with steeper declines in cognition for those with a greater than eighth-grade education. For those with an eighth-grade education or less, time trends did not differ by APOE genotype. A measure of cognitive impairment (i.e., scores of < or = 7 on the Short Portable Mental Status Questionnaire) yielded parallel though weaker evidence for a similar interaction with respect to risk of cognitive impairment. These findings suggest that the presence of at least one e4 allele appears to reduce the protective effects of education for those with at least a ninth-grade education or more, resulting in steeper cognitive declines with age.